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<p>Exosome physiology in the progression of neurodegenerative diseases is intricately tangled with various protein aggregations, including tau protein, α-synuclein, and amyloid-β protein. Exosomes facilitate therapeutic and prognostic avenues through cell-to-cell crosstalk mechanisms, drug delivery, and biomarker isolation strategies in neurodegenerative disease management. The significant implications of molecular insights into neurofibrillary tangles and synaptic dysfunction have been extensively explored through microRNA (miRNA) regulation. The therapeutic potential of exosomes as nano-cargo systems is significant in nervous tissue regeneration and the treatment of neuronal lesions. Advancements in exosome engineering, including genetic modifications, have expanded their capacity to transport RNA molecules, proteins, and novel gene-editing tools such as CRISPR/Cas9, thereby enabling neuroprotective treatment protocols. Integration with immunotherapeutic approaches further highlights exosomes as promising components of combined strategies with important clinical outcomes.</p>

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Decoding the implicit paradigm of exosome targeting blood brain barrier in neurodegenerative diseases: Molecular insight and therapeutic perspective

  • 期刊论文

  • 发表日期：

    2026年3月30日

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  • Rishika Koley,
  • Sriparna De,
  • Adrija Ghosh,
  • Dipanjan Bhattacharjee,
  • Ankan Mitra,
  • Banashree Mondal,
  • Agnish Pahari,
  • Meghasri Nandi,
  • Rachana Kanri,
  • Sanjukta Dasgupta,
  • Dipankar Chattopadhyay

摘要

Exosome physiology in the progression of neurodegenerative diseases is intricately tangled with various protein aggregations, including tau protein, α-synuclein, and amyloid-β protein. Exosomes facilitate therapeutic and prognostic avenues through cell-to-cell crosstalk mechanisms, drug delivery, and biomarker isolation strategies in neurodegenerative disease management. The significant implications of molecular insights into neurofibrillary tangles and synaptic dysfunction have been extensively explored through microRNA (miRNA) regulation. The therapeutic potential of exosomes as nano-cargo systems is significant in nervous tissue regeneration and the treatment of neuronal lesions. Advancements in exosome engineering, including genetic modifications, have expanded their capacity to transport RNA molecules, proteins, and novel gene-editing tools such as CRISPR/Cas9, thereby enabling neuroprotective treatment protocols. Integration with immunotherapeutic approaches further highlights exosomes as promising components of combined strategies with important clinical outcomes.