Scholarlink

Background <p>Self-rated health (SRH) strongly predicts future mortality, even after controlling for various confounding factors. This study investigates two potential confounders of the SRH/mortality relationship—shared family background and genetics.</p> Methods <p>We analyze a dataset of several harmonized twin studies from the integrating genes and environment from multiple studies consortium. Utilizing a within-between twin methodology, we assess whether the SRH/mortality relationship can be explained by social and genetic inheritance.</p> Results <p>Our within-twin estimates are notably lower than the observational estimates, although the difference is statistically non-significant, indicating no substantial confounding from family background. Additionally, we find no significant interaction effects by zygosity, suggesting no confounding from shared genetic factors.</p> Conclusions <p>SRH has been shown to be robust to multiple sources of variation, including demographic sub-groups and contemporary controls for clinical assessments. This study reaffirms the resilience of the SRH/mortality relationship against confounding from shared family background and genetic factors.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Self-rated health and mortality: family background and genetic precursors

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月6日

查看全文
  • Brian Karl Finch,
  • Deborah Finkel,
  • Margaret Gatz,
  • Nancy L. Pedersen,
  • Chandra A. Reynolds,
  • Perminder Sachdev,
  • Amanda Selwood,
  • Nick Martin,
  • Miriam A. Mosing

摘要

Background

Self-rated health (SRH) strongly predicts future mortality, even after controlling for various confounding factors. This study investigates two potential confounders of the SRH/mortality relationship—shared family background and genetics.

Methods

We analyze a dataset of several harmonized twin studies from the integrating genes and environment from multiple studies consortium. Utilizing a within-between twin methodology, we assess whether the SRH/mortality relationship can be explained by social and genetic inheritance.

Results

Our within-twin estimates are notably lower than the observational estimates, although the difference is statistically non-significant, indicating no substantial confounding from family background. Additionally, we find no significant interaction effects by zygosity, suggesting no confounding from shared genetic factors.

Conclusions

SRH has been shown to be robust to multiple sources of variation, including demographic sub-groups and contemporary controls for clinical assessments. This study reaffirms the resilience of the SRH/mortality relationship against confounding from shared family background and genetic factors.