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<p>A recent study in <i>Nature</i> identified the rice (<i>Oryza sativa</i>) nucleotide-binding site and leucine-rich repeat (NLR) receptor XA48, which recognized the ancient bacterial effector XopG and triggered immunity by promoting degradation of the negative regulators OsVOZ1/2. Population genomics revealed an asymmetric selection, with <i>Xa48</i> retained in <i>indica</i> but lost in <i>japonica</i> due to a reproductive penalty. By stacking XA48-mediated effector-triggered immunity (ETI) with XA21-mediated pattern-triggered immunity (PTI) and introducing the compatible Os<i>VOZ1</i><sup><i>S</i></sup> allele, broad-spectrum bacterial blight resistance from wild rice was reconstituted. This work provides a design strategy that helps break the growth-defence trade-off.</p>

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An NLR-VOZ seesaw: from asymmetric selection to synthetic broad-spectrum resistance

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月21日

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  • Yachun Su,
  • Shoujian Zang,
  • Tingting Sun,
  • Chuihuai You,
  • Youxiong Que

摘要

A recent study in Nature identified the rice (Oryza sativa) nucleotide-binding site and leucine-rich repeat (NLR) receptor XA48, which recognized the ancient bacterial effector XopG and triggered immunity by promoting degradation of the negative regulators OsVOZ1/2. Population genomics revealed an asymmetric selection, with Xa48 retained in indica but lost in japonica due to a reproductive penalty. By stacking XA48-mediated effector-triggered immunity (ETI) with XA21-mediated pattern-triggered immunity (PTI) and introducing the compatible OsVOZ1S allele, broad-spectrum bacterial blight resistance from wild rice was reconstituted. This work provides a design strategy that helps break the growth-defence trade-off.