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<p>Plant viruses pose a serious threat to the production of numerous economically valuable food and fuel crops worldwide. Exploring protein interaction networks between viruses and their hosts offers vital insights into the viral infection process and facilitates the development of innovative antiviral strategies for plants. In this review, we aimed to explore commonly used identification methods for protein‒protein interactions (PPIs) and the latest relevant advances, focusing on the advantages and limitations of various PPI identification methods, as well as the role of protein interaction networks involved in virus‒host interactions. This overview of plant‒virus interactions can significantly contribute to insights into viral pathogenesis and innovative strategies for plant antiviral defense.</p>

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The multidimensional significance of virus-host protein interactions and their implications in the antiviral defense of plants

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月14日

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  • Juan Zhang,
  • Chunyan Qi,
  • Zengxu Wu,
  • Yuyu Zhang,
  • Jiangbo Shi,
  • Zejun Li,
  • Jun Guo,
  • Xiangping Zhou,
  • Shen Tang,
  • Jian Yang,
  • Peng Liu

摘要

Plant viruses pose a serious threat to the production of numerous economically valuable food and fuel crops worldwide. Exploring protein interaction networks between viruses and their hosts offers vital insights into the viral infection process and facilitates the development of innovative antiviral strategies for plants. In this review, we aimed to explore commonly used identification methods for protein‒protein interactions (PPIs) and the latest relevant advances, focusing on the advantages and limitations of various PPI identification methods, as well as the role of protein interaction networks involved in virus‒host interactions. This overview of plant‒virus interactions can significantly contribute to insights into viral pathogenesis and innovative strategies for plant antiviral defense.