<p>This study investigates the impact of blast-structure interactions, including shielding and channeling, on blast load characteristics and the associated risk of Primary Blast Injuries (PBIs). The research uniquely quantifies the role of reflective urban surfaces in mitigating blast wave impacts. High-resolution two-dimensional models effectively simulated complex blast dynamics while requiring only 5% of the computational time compared to equivalent three-dimensional models. Four urban scenarios were simulated, representing different structural configurations and environments. A 200-gram TNT charge, comparable to a hand grenade, was detonated. Results were analyzed qualitatively through numerical Schlieren visualizations and quantitatively via overpressure and arrival time data. Validation against experimental data confirmed the accuracy of the simulation. Compared to a free-field explosion, shelter corners can decrease peak overpressure by 33% to 45% when channeling effects are absent. However, with the presence of channeling, this pressure reduction is even greater, reaching 48% to 55%. PBIs such as eardrum rupture, lung damage, and brain hemorrhage were evaluated using established injury criteria. The findings underscore the critical role of structural geometry in shaping blast wave dynamics and injury mitigation. The findings advocate for integrating blast wave behavior explicitly into urban planning and protective barrier design. This integration is necessary within urban resilience frameworks to minimize risks from explosions in densely populated areas.</p>