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<p>The inference of the history of the genetic variability of the novel coronavirus and its variants is essentially based on the presence of gene flow between the viral populations of the different existing and ancestral variants. Our study allowed the detection of numerous gene flows between the endemic variant and a clade composed of two South African and Brazilian variant, using the AIM model part of the StarBeast2 package with MCMC algorithm sampling, we were able to co-infer the SARS_CoV2 tree and its variants alongside the evolutionary parameters of interest. Our study demonstrated a number of gene flows between geographically separated gene pools of SRAS_CoV2 and its mutations, resulting in competition between introduced viral lineages (British; South African; Brazilian) and their endemic ancestors for the sensitive human host. This process will have lasting effects on the structure of the viral population, including the extinction of the endemic lineage, followed by the British variant, and will give way mainly to the clade (South African; Brazilian) Hence the value of increased full genome monitoring of new variants in other isolated geographic areas in order to gain an understanding of the gene flow that occurs between these variants.</p>

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The influence of gene flow on the genetic diversity of SARS-CoV-2 and its variants (British, South African, and Brazilian)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月25日

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  • Nabil Benazi,
  • Sabrina Bounab,
  • Mohammed Khodja,
  • Azzedine Melouki,
  • Hadia Benhalima,
  • Zahra Sadok

摘要

The inference of the history of the genetic variability of the novel coronavirus and its variants is essentially based on the presence of gene flow between the viral populations of the different existing and ancestral variants. Our study allowed the detection of numerous gene flows between the endemic variant and a clade composed of two South African and Brazilian variant, using the AIM model part of the StarBeast2 package with MCMC algorithm sampling, we were able to co-infer the SARS_CoV2 tree and its variants alongside the evolutionary parameters of interest. Our study demonstrated a number of gene flows between geographically separated gene pools of SRAS_CoV2 and its mutations, resulting in competition between introduced viral lineages (British; South African; Brazilian) and their endemic ancestors for the sensitive human host. This process will have lasting effects on the structure of the viral population, including the extinction of the endemic lineage, followed by the British variant, and will give way mainly to the clade (South African; Brazilian) Hence the value of increased full genome monitoring of new variants in other isolated geographic areas in order to gain an understanding of the gene flow that occurs between these variants.