Recently, nanomaterials have been playing an important role in scientific and industrial applications. Silica gel has had the largest share in many fields. Nano-silica gel is manufactured from two different sources under normal atmospheric pressure. After the final drying stage, the samples were exposed to seismic radiation with energy of 10 \({\upmu }\) Ci. The effect of radiation on molecular properties is studied using the spectral and structural analysis before and after irradiation. Raman spectra shown a slight effect on the silica samples during all periods. The also indicated shifts towards short wavelengths in the silica region and a long shift in the water region, which confirms the possibility of trapping rays within the pores, in addition to studying the surface topography and morphology, it founds there was no obvious change in all the samples’ radiation, including cracks, and they maintained their porous structure even after radiation exposure during the long periods. The results indicated a slight effect on the silica samples throughout all periods, suggesting the need for further studies using different types of radioactive sources over extended durations to evaluate whether nano-silica could be a promising material for radiation insulation.