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<p>Recently, interest in bioactive glasses has surged, recognized for their exceptional bioactivity and therapeutic potential in bone regeneration. Zn<sup>+2</sup> ions, essential for cell growth and maturation, could enhance the regeneration ability of these glasses. Recognized for its significant impact on material properties, laser irradiation presents a novel method for inducing nanoparticle precipitation within the glass matrix, thereby enhancing bone regeneration. Using melt quenching techniques, glass samples based on the B<sub>2</sub>O<sub>3</sub>, 24.5 CaO, 24.5 Na<sub>2</sub>O, and 6 P<sub>2</sub>O<sub>5</sub> systems, doped ZnO (5 wt% and 10 wt %) were synthesized. After being irradiated with a Nd:YAG nanosecond (ns) laser, the samples were tested for their bioactivity in simulated body fluid (SBF). FTIR analysis showed that after four weeks of radiation and SBF exposure, clear Far-IR peaks at around 570 and 540&#xa0;cm⁻<sup>1</sup> appeared. This confirmed the formation of a hydroxyapatite (HA) layer.&#xa0;Following immersion in the SBF solution, the XRD analysis also confirmed the presence of ordered crystalline phases and the HA layer. The SEM images showed a shape like cotton, and the UV–visible spectroscopy showed better optical properties. Collectively, these results show that the HA layer developed successfully after laser treatment. Combining nanosecond laser irradiation with zinc-doped borate glass offers potential for innovative progress in bone regeneration techniques.</p>

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Nano-second laser-irradiated ZnO-doped borate glass for bone tissue engineering: structural and optical studies

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月23日

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  • Nahla. M. Salatein,
  • A. M. Abdelghany,
  • Irene S. Fahim,
  • F. A. ElHussiny,
  • Y. Abdou

摘要

Recently, interest in bioactive glasses has surged, recognized for their exceptional bioactivity and therapeutic potential in bone regeneration. Zn+2 ions, essential for cell growth and maturation, could enhance the regeneration ability of these glasses. Recognized for its significant impact on material properties, laser irradiation presents a novel method for inducing nanoparticle precipitation within the glass matrix, thereby enhancing bone regeneration. Using melt quenching techniques, glass samples based on the B2O3, 24.5 CaO, 24.5 Na2O, and 6 P2O5 systems, doped ZnO (5 wt% and 10 wt %) were synthesized. After being irradiated with a Nd:YAG nanosecond (ns) laser, the samples were tested for their bioactivity in simulated body fluid (SBF). FTIR analysis showed that after four weeks of radiation and SBF exposure, clear Far-IR peaks at around 570 and 540 cm⁻1 appeared. This confirmed the formation of a hydroxyapatite (HA) layer. Following immersion in the SBF solution, the XRD analysis also confirmed the presence of ordered crystalline phases and the HA layer. The SEM images showed a shape like cotton, and the UV–visible spectroscopy showed better optical properties. Collectively, these results show that the HA layer developed successfully after laser treatment. Combining nanosecond laser irradiation with zinc-doped borate glass offers potential for innovative progress in bone regeneration techniques.