Scholarlink

Challenge <p>The Hodgkin-Huxley membrane conductance model has been featured in biomedical engineering (BME) curricula for decades. A typical BME assignment might require students to apply the relevant equations and parameters to model the generation of action potentials; however, there is opportunity for students to build and explore both deterministic and stochastic models of ion channel behavior.</p> Novel Initiative <p>We have developed two projects that involve building mathematical Hodgkin-Huxley models, which are delivered in a required two-course sequence in the third year of our BME undergraduate curriculum. In the first project, students build and explore a deterministic Hodgkin-Huxley model, using numerical computing to solve differential equations. In the second project, students build stochastic models of individual potassium ion channels and whole cells by performing repeated simulations of ion channel states.</p> Reflection <p>Incorporating these applied, biomedically relevant projects offers many of the benefits of Project-based Learning (PBL), including building skills in critical thinking, problem solving, programming, and written communication.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A Two-part Approach to the Hodgkin-Huxley Project: Challenging Students to Build Deterministic and Stochastic Models of Ion Channel Behavior

  • 期刊论文

  • 发表日期：

    2025年3月10日

查看全文
  • Steven Higbee,
  • Sharon Miller,
  • Karen Alfrey

摘要

Challenge

The Hodgkin-Huxley membrane conductance model has been featured in biomedical engineering (BME) curricula for decades. A typical BME assignment might require students to apply the relevant equations and parameters to model the generation of action potentials; however, there is opportunity for students to build and explore both deterministic and stochastic models of ion channel behavior.

Novel Initiative

We have developed two projects that involve building mathematical Hodgkin-Huxley models, which are delivered in a required two-course sequence in the third year of our BME undergraduate curriculum. In the first project, students build and explore a deterministic Hodgkin-Huxley model, using numerical computing to solve differential equations. In the second project, students build stochastic models of individual potassium ion channels and whole cells by performing repeated simulations of ion channel states.

Reflection

Incorporating these applied, biomedically relevant projects offers many of the benefits of Project-based Learning (PBL), including building skills in critical thinking, problem solving, programming, and written communication.