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<p>Biomolecule analysis plays a vital role in early disease diagnosis, personalized nutrition, food science, and basic biomedical research. Yet, current technologies face fundamental trade-offs between each pair of the parameters including sensitivity, throughput and cost. In this work, a scalable platform for biomolecule sensing was proposed based on amorphous gallium oxide (a-Ga<sub>2</sub>O<sub>3</sub>) thin film considering its remarkable deep ultraviolet (UV) response property and unique low-temperature compatibility with large-area electronics. A single-pixel a-Ga<sub>2</sub>O<sub>3</sub> photodetector with a peak responsivity of 0.65&#xa0;A/W at 255&#xa0;nm was first employed to identify four basic biomolecules including adenine, guanine, L-phenylalanine, and L-tyrosine. The concentration-dependent photocurrent varied in good agreement with their distinct UV absorbance properties verified by a commercial UV-Vis spectrometer. Further, a 64 × 64 deep UV imaging array was constructed by directly depositing the a-Ga<sub>2</sub>O<sub>3</sub> film onto a commercial amorphous silicon (a-Si) thin-film transistor (TFT) backplane, successfully achieving a high-throughput imaging of the four biomolecules. These results establish a viable strategy for a portable, miniaturized and cost-effective biomolecule sensing circuit with rapid and label-free detection.</p>

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Amorphous Ga2O3 deep UV imager for label-free biomolecule detection

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月29日

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  • Wei Cai,
  • Huili Liang,
  • Weijing Han,
  • Rui Zhu,
  • Ye Zhang,
  • Wei Zheng,
  • Zengxia Mei

摘要

Biomolecule analysis plays a vital role in early disease diagnosis, personalized nutrition, food science, and basic biomedical research. Yet, current technologies face fundamental trade-offs between each pair of the parameters including sensitivity, throughput and cost. In this work, a scalable platform for biomolecule sensing was proposed based on amorphous gallium oxide (a-Ga2O3) thin film considering its remarkable deep ultraviolet (UV) response property and unique low-temperature compatibility with large-area electronics. A single-pixel a-Ga2O3 photodetector with a peak responsivity of 0.65 A/W at 255 nm was first employed to identify four basic biomolecules including adenine, guanine, L-phenylalanine, and L-tyrosine. The concentration-dependent photocurrent varied in good agreement with their distinct UV absorbance properties verified by a commercial UV-Vis spectrometer. Further, a 64 × 64 deep UV imaging array was constructed by directly depositing the a-Ga2O3 film onto a commercial amorphous silicon (a-Si) thin-film transistor (TFT) backplane, successfully achieving a high-throughput imaging of the four biomolecules. These results establish a viable strategy for a portable, miniaturized and cost-effective biomolecule sensing circuit with rapid and label-free detection.