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<p>With the prevalence of antibiotic-resistant bacteria (ARB), the antibacterial strategy based on combining multiple antibacterial pathways in one agent provides a promising way to combat ARB infections. Here, we reported that bovine serum albumin (BSA)-Ag<sub>2</sub>Te nanoparticles (NPs) could partially recover the antibacterial activity of ineffective β-lactam antibiotic cefotaxime (CTX) against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) by inhibiting β-lactamase and increasing membrane permeability of MRSA. The lower fractional inhibitory concentration index (0.187) and the combination index (≤ 0.68 ) provided the higher synergistic bactericidal activity of BSA-Ag<sub>2</sub>Te and CTX. Furthermore, BSA-Ag<sub>2</sub>Te NPs exhibited high near-infrared (NIR)-induced photothermal conversion and NIR-enhanced peroxidase-mimicking activities. Both the hyperthermia produced by NIR irradiation and <b>·</b>OH generated through catalyzing H<sub>2</sub>O<sub>2</sub> significantly enhanced the synergistic antibacterial activity of BSA-Ag<sub>2</sub>Te with CTX against MRSA. Over a short irradiation time (10&#xa0;min), BSA-Ag<sub>2</sub>Te + CTX + H<sub>2</sub>O<sub>2</sub> + NIR decreased 3.8 log<sub>10</sub> of MRSA, which is higher than that of BSA-Ag<sub>2</sub>Te + CTX + NIR (2.8 log<sub>10</sub>) or BSA-Ag<sub>2</sub>Te + CTX + H<sub>2</sub>O<sub>2</sub> (1.4 log<sub>10</sub>). Such a multiple-mode antibacterial platform based on BSA-Ag<sub>2</sub>Te NPs and ineffective CTX may provide an effective strategy to overcome refractory MRSA infections.</p>

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NIR enhanced nanozyme and synergy with ineffective antibiotic activities of BSA-Ag2Te for MRSA eradication

  • 期刊论文

  • 发表日期：

    2026年2月3日

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  • Deyou Zhao,
  • Songtai Gao,
  • Xiaowei Tian,
  • Xiaowen Liu,
  • Zhong Lu,
  • Huaiying Yao

摘要

With the prevalence of antibiotic-resistant bacteria (ARB), the antibacterial strategy based on combining multiple antibacterial pathways in one agent provides a promising way to combat ARB infections. Here, we reported that bovine serum albumin (BSA)-Ag2Te nanoparticles (NPs) could partially recover the antibacterial activity of ineffective β-lactam antibiotic cefotaxime (CTX) against methicillin-resistant Staphylococcus aureus (MRSA) by inhibiting β-lactamase and increasing membrane permeability of MRSA. The lower fractional inhibitory concentration index (0.187) and the combination index (≤ 0.68 ) provided the higher synergistic bactericidal activity of BSA-Ag2Te and CTX. Furthermore, BSA-Ag2Te NPs exhibited high near-infrared (NIR)-induced photothermal conversion and NIR-enhanced peroxidase-mimicking activities. Both the hyperthermia produced by NIR irradiation and ·OH generated through catalyzing H2O2 significantly enhanced the synergistic antibacterial activity of BSA-Ag2Te with CTX against MRSA. Over a short irradiation time (10 min), BSA-Ag2Te + CTX + H2O2 + NIR decreased 3.8 log10 of MRSA, which is higher than that of BSA-Ag2Te + CTX + NIR (2.8 log10) or BSA-Ag2Te + CTX + H2O2 (1.4 log10). Such a multiple-mode antibacterial platform based on BSA-Ag2Te NPs and ineffective CTX may provide an effective strategy to overcome refractory MRSA infections.