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<p>In this work, the development of π-conjugated chromophore nanoparticles using starch as a biopolymer stabilizer is reported. Starch was extracted from <i>Amaranthus hypochondriacus</i> seeds via an environmentally friendly aqueous method. The extracted starch served as a biocompatible stabilizing matrix for the preparation of nanosystems incorporating bisquinoline derivatives (BQ1 and BQ2) and a diketopyrrolopyrrole derivative (DPP-BisTPA) through a controlled reprecipitation process in an aqueous medium. The starch-stabilized nanoaggregates exhibited average hydrodynamic diameters of less than 100&#xa0;nm, as determined by DLS, and negative zeta potential values, indicating colloidal stability. UV–Vis and photoluminescence analyses indicate that starch encapsulation does not alter the NLO or AIE properties of the model fluorophores (BQ1 and BQ2). Similarly, the model photosensitizer (DPP-BisTPA) maintains its singlet oxygen generation efficiency. Overall, these starch-derived nanosystems represent a biodegradable and sustainable platform for the development of nanophotosensitisers and fluorescent probes with potential applications in bioimaging and photodynamic therapy.</p> Graphical abstract <p></p>

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Biopolymeric stabilization of photonic nanoaggregates using amaranth starch: toward applications in bioimaging and photodynamic therapy

  • 期刊论文

  • 发表日期：

    2025年12月3日

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  • Román Leyva López,
  • F. Yedith Rodríguez-Hernández,
  • Thamara Iturbide-Pichardo,
  • O. Javier Hernández-Ortiz

摘要

In this work, the development of π-conjugated chromophore nanoparticles using starch as a biopolymer stabilizer is reported. Starch was extracted from Amaranthus hypochondriacus seeds via an environmentally friendly aqueous method. The extracted starch served as a biocompatible stabilizing matrix for the preparation of nanosystems incorporating bisquinoline derivatives (BQ1 and BQ2) and a diketopyrrolopyrrole derivative (DPP-BisTPA) through a controlled reprecipitation process in an aqueous medium. The starch-stabilized nanoaggregates exhibited average hydrodynamic diameters of less than 100 nm, as determined by DLS, and negative zeta potential values, indicating colloidal stability. UV–Vis and photoluminescence analyses indicate that starch encapsulation does not alter the NLO or AIE properties of the model fluorophores (BQ1 and BQ2). Similarly, the model photosensitizer (DPP-BisTPA) maintains its singlet oxygen generation efficiency. Overall, these starch-derived nanosystems represent a biodegradable and sustainable platform for the development of nanophotosensitisers and fluorescent probes with potential applications in bioimaging and photodynamic therapy.

Graphical abstract