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<p>Hydrogen sulfide (H<sub>2</sub>S) holds a distinct role in cell biology. Its level is intricately linked to the homeostasis of the biological environment, underscoring the significance of developing techniques capable of detecting H<sub>2</sub>S in biological systems. A single probe that offers versatility across different detection techniques opens opportunities for advancements in sensing H<sub>2</sub>S in various fields. A nitronaphthalimide derivative, NMO prepared using a simple synthetic protocol, has been studied as an electrochemical, colorimetric, and turn-on fluorescence probe for H<sub>2</sub>S. NMO displayed a detection limit of 9.95&#xa0;mM and 4.36&#xa0;mM in the UV–visible and colorimetric studies, respectively, whereas the fluorometric and square wave techniques confirmed lower detection limits of 98.4&#xa0;μM and 1.24&#xa0;mM, correspondingly. Further, the real-time imaging of HEK293T cells using NMO during stress-induced autophagy is demonstrated.</p> Graphical Abstract <p></p>

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A versatile electrochemical, colorimetric, and visible light excitable turn-on fluorescent probe for stress-induced H2S detection

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月22日

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  • M. Ranjana,
  • M. S. Shrilaxmi,
  • Probal Nag,
  • Prajoy Kumar Mitra,
  • Dhanya Sunil,
  • Somasish Ghosh Dastidar,
  • Y. N. Sudhakar,
  • Sivaranjana Reddy Vennapusa,
  • Ramesh Raju,
  • Ilkka Tittonen,
  • Dinesh Upadhya

摘要

Hydrogen sulfide (H2S) holds a distinct role in cell biology. Its level is intricately linked to the homeostasis of the biological environment, underscoring the significance of developing techniques capable of detecting H2S in biological systems. A single probe that offers versatility across different detection techniques opens opportunities for advancements in sensing H2S in various fields. A nitronaphthalimide derivative, NMO prepared using a simple synthetic protocol, has been studied as an electrochemical, colorimetric, and turn-on fluorescence probe for H2S. NMO displayed a detection limit of 9.95 mM and 4.36 mM in the UV–visible and colorimetric studies, respectively, whereas the fluorometric and square wave techniques confirmed lower detection limits of 98.4 μM and 1.24 mM, correspondingly. Further, the real-time imaging of HEK293T cells using NMO during stress-induced autophagy is demonstrated.

Graphical Abstract