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<p>Multiple health problems are associated with either over- or under-exposure to ultraviolet (UV) radiation. Using an agent-based microsimulation model, we examined the joint health and economic effects of conditions arising from over-exposure to sunlight (i.e., melanoma, keratinocyte skin carcinoma (KC) and cataract) and under-exposure to sunlight via vitamin D deficiency (i.e., fragility fractures and multiple sclerosis). We developed an agent-based model to estimate and compare incident cases, disease-specific deaths, healthcare costs and losses in quality-adjusted life years (QALYs) attributable to over- or under-exposure to UV radiation. Simulations were performed over a 20-year period for populations in 14 locations across Australia and New Zealand. Conditions caused by over-exposure to UV radiation were predicted to result in 6.0 and 1.2 million new cases compared with 0.12 and 0.08 million cases from under-exposure in Australia and New Zealand, respectively. However, the number of deaths due to under-exposure (Australia: 58,503; New Zealand: 20,104) were higher than those arising from over-exposure (Australia: 49,320; New Zealand: 7136), but this was dependent on the definition of vitamin D deficiency used. The expected healthcare costs from over-exposure to UV radiation were AU$12.4 billion in Australia and NZ$5.2 billion in New Zealand, three-fold higher than costs for conditions attributable to under-exposure in both countries. Despite the enormous burden of skin cancers, highlighting the importance of sun protection, avoidable deaths and healthcare costs of fragility fractures due to a lack of UV radiation requires a reduction in vitamin D deficiency in Australians and New Zealanders.</p> Graphical abstract <p></p>

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Estimated health and economic effects associated with over- and under-exposure to solar ultraviolet radiation in Australia and New Zealand using the SUNEX simulation model

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月28日

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  • Louisa G. Collins,
  • Thomas M. Elliott,
  • Ann Webb,
  • Ian R. Reid,
  • Craig Sinclair,
  • Tracy Comans,
  • Jonathan Karnon,
  • Anna Foeglein,
  • Karen van Gorp,
  • Vanessa Fanning,
  • Rachel E. Neale

摘要

Multiple health problems are associated with either over- or under-exposure to ultraviolet (UV) radiation. Using an agent-based microsimulation model, we examined the joint health and economic effects of conditions arising from over-exposure to sunlight (i.e., melanoma, keratinocyte skin carcinoma (KC) and cataract) and under-exposure to sunlight via vitamin D deficiency (i.e., fragility fractures and multiple sclerosis). We developed an agent-based model to estimate and compare incident cases, disease-specific deaths, healthcare costs and losses in quality-adjusted life years (QALYs) attributable to over- or under-exposure to UV radiation. Simulations were performed over a 20-year period for populations in 14 locations across Australia and New Zealand. Conditions caused by over-exposure to UV radiation were predicted to result in 6.0 and 1.2 million new cases compared with 0.12 and 0.08 million cases from under-exposure in Australia and New Zealand, respectively. However, the number of deaths due to under-exposure (Australia: 58,503; New Zealand: 20,104) were higher than those arising from over-exposure (Australia: 49,320; New Zealand: 7136), but this was dependent on the definition of vitamin D deficiency used. The expected healthcare costs from over-exposure to UV radiation were AU$12.4 billion in Australia and NZ$5.2 billion in New Zealand, three-fold higher than costs for conditions attributable to under-exposure in both countries. Despite the enormous burden of skin cancers, highlighting the importance of sun protection, avoidable deaths and healthcare costs of fragility fractures due to a lack of UV radiation requires a reduction in vitamin D deficiency in Australians and New Zealanders.

Graphical abstract