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<p>Recent studies have shown that the efficacy of probiotic interventions may vary among individuals of different ethnicities. Ethnic groups residing in different parts of the planet harbouring distinct sets of microbes in their gut and often having contrasting dietary preferences. We employed technique of Flux Balance Analysis to simulate the effect of probiotic interventions on varying gut microbiota compositions and diet. We defined two novel metrics, namely, ‘Net-effect’ and ‘Sustainability’ to quantify the efficacy of probiotic supplementation and demonstrated how the growth of the probiotic organisms as well as the benefits derived from them varied across gut-microbiota-types and diet compositions. Based on the results we present a hypothesis that the efficacy of probiotic intervention is dependent on both the gut microbiota composition as well as the individual’s dietary preferences.</p>

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Should probiotic recommendation be customized to diet and gut microbiota make-up? Insights from in silico metabolic simulations

  • 期刊论文

  • 发表日期：

    2026年3月27日

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  • Rohan Singh,
  • Nishal Kumar Pinna,
  • Tungadri Bose,
  • Anirban Dutta,
  • Sharmila S. Mande

摘要

Recent studies have shown that the efficacy of probiotic interventions may vary among individuals of different ethnicities. Ethnic groups residing in different parts of the planet harbouring distinct sets of microbes in their gut and often having contrasting dietary preferences. We employed technique of Flux Balance Analysis to simulate the effect of probiotic interventions on varying gut microbiota compositions and diet. We defined two novel metrics, namely, ‘Net-effect’ and ‘Sustainability’ to quantify the efficacy of probiotic supplementation and demonstrated how the growth of the probiotic organisms as well as the benefits derived from them varied across gut-microbiota-types and diet compositions. Based on the results we present a hypothesis that the efficacy of probiotic intervention is dependent on both the gut microbiota composition as well as the individual’s dietary preferences.