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<p><i>Salmonella</i> infections have far-reaching implications for public health due to their potential to cause various human illnesses, ranging from gastroenteritis to more severe conditions like enteric fever. These infections are predominantly food-borne and are often linked to consuming contaminated meat products, with poultry being a common transmission source. Consequently, Salmonellosis ranks among the most prevalent food-borne illnesses, leading to substantial morbidity, hospitalizations, and even fatalities. In this study, we investigated the role of circular RNAs (circRNAs) in mediating the response to <i>Salmonella</i> Typhimurium infection in poultry, focusing on two chicken breeds: broilers (susceptible) and <i>Kashmir Faverolla</i> (resistant). Through high-throughput RNA sequencing, we identified and analyzed circRNA expression patterns in liver and spleen samples from both breeds. Results reveal a comprehensive catalog of circRNAs, with 26 differentially expressed (DE) circRNAs identified across various comparison groups. Our study revealed that the circRNAs associated with genes conferring resistance to <i>Kashmir Faverolla</i> are predominantly located on chromosome 1, with a notable presence also observed on chromosome 4. Moreover, genes <i>FGB, FGG,</i> and <i>ALB</i> could play pivotal roles in mediating the response to <i>Salmonella</i> infection in poultry. Network analyses and protein–protein interaction networks shed light on the interconnectedness of genes like <i>FGB, FGG</i>, and <i>ALB</i>, suggesting their collaborative roles in mediating the response to <i>Salmonella</i> infection. Overall, our findings provide a comparative overview of circRNA expression profiles in broiler and Kashmir faverolla chickens during Salmonella infection. The identified circRNA-associated host genes, including FGG and FGB, were enriched in immune- and coagulation-related pathways, suggesting potential involvement in breed-specific responses to infection. These results offer predictive insights into circRNA-mediated regulatory networks and provide a foundation for future functional validation studies.</p>

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Genome-wide identification of circular RNAs linked to Salmonella resistance in chicken

  • 期刊论文

  • 发表日期：

    2026年3月10日

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  • Mahak Khan,
  • Mashooq Ahmad Dar,
  • Hina Fayaz Bhat,
  • Nadeem Shabir,
  • Sabia Qureshi,
  • Mudasir Bashir Gugjoo,
  • Javeed Iqbal Ahmad Bhat,
  • Shabir Mir,
  • Basharat Bhat,
  • Syed Mudasir Ahmad

摘要

Salmonella infections have far-reaching implications for public health due to their potential to cause various human illnesses, ranging from gastroenteritis to more severe conditions like enteric fever. These infections are predominantly food-borne and are often linked to consuming contaminated meat products, with poultry being a common transmission source. Consequently, Salmonellosis ranks among the most prevalent food-borne illnesses, leading to substantial morbidity, hospitalizations, and even fatalities. In this study, we investigated the role of circular RNAs (circRNAs) in mediating the response to Salmonella Typhimurium infection in poultry, focusing on two chicken breeds: broilers (susceptible) and Kashmir Faverolla (resistant). Through high-throughput RNA sequencing, we identified and analyzed circRNA expression patterns in liver and spleen samples from both breeds. Results reveal a comprehensive catalog of circRNAs, with 26 differentially expressed (DE) circRNAs identified across various comparison groups. Our study revealed that the circRNAs associated with genes conferring resistance to Kashmir Faverolla are predominantly located on chromosome 1, with a notable presence also observed on chromosome 4. Moreover, genes FGB, FGG, and ALB could play pivotal roles in mediating the response to Salmonella infection in poultry. Network analyses and protein–protein interaction networks shed light on the interconnectedness of genes like FGB, FGG, and ALB, suggesting their collaborative roles in mediating the response to Salmonella infection. Overall, our findings provide a comparative overview of circRNA expression profiles in broiler and Kashmir faverolla chickens during Salmonella infection. The identified circRNA-associated host genes, including FGG and FGB, were enriched in immune- and coagulation-related pathways, suggesting potential involvement in breed-specific responses to infection. These results offer predictive insights into circRNA-mediated regulatory networks and provide a foundation for future functional validation studies.