Scholarlink

Background <p>The main bioactive phytochemical found in <i>Curcuma longa</i> L., or turmeric, is curcumin.</p> Aim <p>Curcumin’s antibacterial spectrum and antibiofilm impact against MDR (Multidrug-Resistant) are assessed in this study.</p> Methods <p>From the oral cavity and burns and wounds on the skin, the following bacteria were isolated: <i>Klebsiella pneumonia</i>, <i>Klebsiella oxytoca, Acinetobacter baumannii</i>, <i>Staphylococcus aureus</i>, <i>Staphylococcus epidermidis,</i> and <i>Kocuria rosea</i>. The VITEK (Automated Microbial Identification System) was used to confirm the diagnosis of bacteria. Conversely, the antibiofilm properties of curcumin were assessed using the Congo red agar and TCP (Tissue Culture Plate) techniques.</p> Results <p>Based on the results, Curcumin demonstrated a 50% reduction in bacterial growth at a concentration of 250&#xa0;µg/ml compared to the control. Curcumin was threefold more effective than antibiotic C at inhibiting the growth of <i>Staphylococcus aureus</i>. An investigation was conducted on <i>Staphylococcus aureus</i> for the biofilm since it is notoriously known for its capacity to produce biofilm. The insilico analysis the structure of Filamenting temperature-sensitive mutant Z (FtsZ) (PDB ID:3VO8) and Curcumin with Molecular Formula(C<sub>21</sub>H<sub>20</sub>O<sub>6</sub>) as representative models. The results revealed that Curcumin can interact with the active site of FtsZ (PDB ID:3VO8) observed at the most significant areas, 1324.243, and a volume of 1218.594 amino acids. It is considered an attractive target for antibacterial drug development. Inhibitors of FtsZ have the potential to block bacterial division and serve as novel treatments for bacterial infection.</p> Conclusions <p>Besides offering initial insights into the possible binding of (FtsZ) (PDB ID:3VO8) in the context of upcoming antibacterial drug development research, these data demonstrate the value of molecular identification for diagnosis and management.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Antibacterial and antibiofilm activity of curcumin against multidrug-resistant bacteria: insights into FtsZ inhibition and mechanistic pathway

  • 期刊论文

  • 发表日期：

    2025年11月26日

查看全文
  • Yasser Ali Hussein,
  • Maryam Dhary Kamel,
  • Maryam Hussein Aldabbas,
  • Rand Jabbar Sattar,
  • Hind Majid Ahmed,
  • Majid S. Jabir,
  • Zahraa Mohsin Zghair,
  • Zahraa Abbas Fadhil,
  • Nameera Ghazi Abdulkarem Alaw,
  • Ghassan M. Sulaiman,
  • Buthenia A. Hasoon

摘要

Background

The main bioactive phytochemical found in Curcuma longa L., or turmeric, is curcumin.

Aim

Curcumin’s antibacterial spectrum and antibiofilm impact against MDR (Multidrug-Resistant) are assessed in this study.

Methods

From the oral cavity and burns and wounds on the skin, the following bacteria were isolated: Klebsiella pneumonia, Klebsiella oxytoca, Acinetobacter baumannii, Staphylococcus aureus, Staphylococcus epidermidis, and Kocuria rosea. The VITEK (Automated Microbial Identification System) was used to confirm the diagnosis of bacteria. Conversely, the antibiofilm properties of curcumin were assessed using the Congo red agar and TCP (Tissue Culture Plate) techniques.

Results

Based on the results, Curcumin demonstrated a 50% reduction in bacterial growth at a concentration of 250 µg/ml compared to the control. Curcumin was threefold more effective than antibiotic C at inhibiting the growth of Staphylococcus aureus. An investigation was conducted on Staphylococcus aureus for the biofilm since it is notoriously known for its capacity to produce biofilm. The insilico analysis the structure of Filamenting temperature-sensitive mutant Z (FtsZ) (PDB ID:3VO8) and Curcumin with Molecular Formula(C21H20O6) as representative models. The results revealed that Curcumin can interact with the active site of FtsZ (PDB ID:3VO8) observed at the most significant areas, 1324.243, and a volume of 1218.594 amino acids. It is considered an attractive target for antibacterial drug development. Inhibitors of FtsZ have the potential to block bacterial division and serve as novel treatments for bacterial infection.

Conclusions

Besides offering initial insights into the possible binding of (FtsZ) (PDB ID:3VO8) in the context of upcoming antibacterial drug development research, these data demonstrate the value of molecular identification for diagnosis and management.