Scholarlink

<p>Male infertility is a multifaceted medical condition that has a detrimental effect on reproductive health worldwide. Testicular dysfunction is mainly associated with oxidative damage caused by an unhealthy contemporary lifestyle. The present work employed an <i>ex vivo</i> experimental model to investigate the preventive effect of resveratrol, derived from <i>Elaeagnus pyriformis</i> Hook.f fruit, against H<sub>2</sub>O<sub>2</sub>-mediated oxidative testicular damage. An increasing dose (5, 10, 20, 40&#xa0;mg/L) of resveratrol demonstrated protection against H<sub>2</sub>O<sub>2</sub>-induced oxidative injury and increased sperm viability by up-regulating several frontline enzymatic and non-enzymatic antioxidants, such as SOD (~ 165 to 172%), CAT (~ 16 to 38%), and GSH (~ 18.5 to 91.43%), respectively. Resveratrol reduces NOX enzyme activity (~ 39 to 55%), improves altered lipid metabolism, and regenerates histological architectures. The results are corroborated by an <i>in-silico</i> analysis, which revealed that resveratrol has a significant inhibitory potential (− 7.8&#xa0;kcal/mol) against the stress protein NOX2. Consequently, this polyphenol has the potential to be an effective remedy for male infertility problems caused by oxidative stress.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Protective effects of silverberry (Elaeagnus pyriformis Hook.f) on oxidative stress-induced male reproductive dysfunction: an ex vivo study

  • 期刊论文

  • 发表日期：

    2025年11月10日

查看全文
  • Swarnendra Banerjee,
  • Usashi Shome,
  • Sourik Mondal,
  • Rejuan Islam,
  • Tilak Saha,
  • Churyukina Ella V.,
  • Arnab Sen

摘要

Male infertility is a multifaceted medical condition that has a detrimental effect on reproductive health worldwide. Testicular dysfunction is mainly associated with oxidative damage caused by an unhealthy contemporary lifestyle. The present work employed an ex vivo experimental model to investigate the preventive effect of resveratrol, derived from Elaeagnus pyriformis Hook.f fruit, against H2O2-mediated oxidative testicular damage. An increasing dose (5, 10, 20, 40 mg/L) of resveratrol demonstrated protection against H2O2-induced oxidative injury and increased sperm viability by up-regulating several frontline enzymatic and non-enzymatic antioxidants, such as SOD (~ 165 to 172%), CAT (~ 16 to 38%), and GSH (~ 18.5 to 91.43%), respectively. Resveratrol reduces NOX enzyme activity (~ 39 to 55%), improves altered lipid metabolism, and regenerates histological architectures. The results are corroborated by an in-silico analysis, which revealed that resveratrol has a significant inhibitory potential (− 7.8 kcal/mol) against the stress protein NOX2. Consequently, this polyphenol has the potential to be an effective remedy for male infertility problems caused by oxidative stress.

Graphical abstract