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Introduction <p>Hemoglobinopathies are common genetic disorders of hemoglobin, which can be prevented by population screening and genetic counseling. India is within the thalassemia belt of the world where the carrier frequency ranges between1 and 17%.The remote areas of West Midnaporeis not so much explored till now and population screening is essential among the pre-marital age group for identification and inhibition of high-risk marriages.</p> Objective <p>The present study was undertaken to find out the spectrum of hemoglobinopathies among the college going students.</p> Materials and methods <p>A total of 221 college going students of Ghatal Rabindra Satabarsiki Mahavidyalaya (GRSM) were screened. Cases were diagnosed as thalassemias and hemoglobinopathies by Bio- Rad variant II HPLC system by β-thal short program. The retention times, proportion of the haemoglobin (%), and peak characteristics for all hemoglobin (Hb) fractions were documented.</p> Results <p>Amongst 221 cases included in the present study and 17 (7.69%) were identified to have thalassemia trait. Out of them, 9 (4.07%) cases had β-thalassemia trait, 6 (2.71%) cases of HbE-trait. There was one subject with HbD-Punjab variant and another one was compound heterozygote for HbE and HbS hemoglobin variant.</p> Conclusions <p>The screening for thalassemia should be included as a part of regular blood testing among the college going students which will provide idea about the extent of hemoglobinopathy in the rural area of West Midnapore.</p>

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Thalassemia carrier screening among the college going students of the rural areas of West Midnapore, India

  • 期刊论文

  • 发表日期：

    2025年1月3日

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  • Amrita Panja,
  • Biplab Kahar,
  • Mantu Kumar Das,
  • Tuphan Kanti Dolai

摘要

Introduction

Hemoglobinopathies are common genetic disorders of hemoglobin, which can be prevented by population screening and genetic counseling. India is within the thalassemia belt of the world where the carrier frequency ranges between1 and 17%.The remote areas of West Midnaporeis not so much explored till now and population screening is essential among the pre-marital age group for identification and inhibition of high-risk marriages.

Objective

The present study was undertaken to find out the spectrum of hemoglobinopathies among the college going students.

Materials and methods

A total of 221 college going students of Ghatal Rabindra Satabarsiki Mahavidyalaya (GRSM) were screened. Cases were diagnosed as thalassemias and hemoglobinopathies by Bio- Rad variant II HPLC system by β-thal short program. The retention times, proportion of the haemoglobin (%), and peak characteristics for all hemoglobin (Hb) fractions were documented.

Results

Amongst 221 cases included in the present study and 17 (7.69%) were identified to have thalassemia trait. Out of them, 9 (4.07%) cases had β-thalassemia trait, 6 (2.71%) cases of HbE-trait. There was one subject with HbD-Punjab variant and another one was compound heterozygote for HbE and HbS hemoglobin variant.

Conclusions

The screening for thalassemia should be included as a part of regular blood testing among the college going students which will provide idea about the extent of hemoglobinopathy in the rural area of West Midnapore.