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Background <p>Bio-Active Composite Therapy (BACT) represents a significant advancement in regenerative orthopaedics, integrating bioactive materials with biological systems to enhance bone and tissue regeneration. This comprehensive approach leverages materials such as hydroxyapatite, bioactive glasses, polymers, and metals to create scaffolds that mimic the extracellular matrix, facilitating cellular activities essential for tissue repair.</p> Methods <p>A systematic literature review was conducted using databases including PubMed, Scopus, Web of Science, and Google Scholar. Keywords such as “Bio-Active Composite Therapy,” “regenerative orthopaedics,” and “bioactive materials” were employed to identify relevant studies published between 2000 and 2024. Inclusion criteria focused on peer-reviewed articles, reviews, and clinical trials related to the development, application, and evaluation of BACT in bone and soft tissue regeneration. Data extraction emphasized bioactive material types, fabrication techniques, clinical applications, outcomes, and associated challenges. The findings were categorized thematically to synthesize current advancements and identify knowledge gaps.</p> Results <p>BACT utilizes a diverse range of bioactive materials, with hydroxyapatite and bioactive glasses being predominant due to their osteoconductive and osteoinductive properties. Advanced fabrication techniques, particularly additive manufacturing (e.g., 3D printing), enable the creation of scaffolds with precise geometries and tailored porosity, enhancing cellular adhesion and proliferation. Clinically, BACT has demonstrated efficacy in bone regeneration, cartilage repair, and ligament healing, although biocompatibility and immunotoxicity remain challenges, especially with certain metal oxides like TiO₂. Economic barriers and technical precision in scaffold application also pose significant limitations.</p> Conclusion <p>BACT holds transformative potential in regenerative orthopaedics by offering tailored, effective treatments for musculoskeletal disorders. Overcoming biocompatibility, safety, and accessibility challenges through interdisciplinary collaboration and technological innovation is essential for its widespread clinical adoption. Future research should focus on optimizing bioactive materials and fabrication methods, alongside rigorous clinical trials to validate long-term efficacy and safety.</p> Graphical Abstract <p></p>

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Bio-Active Composite Therapy (BACT) in Regenerative Orthopaedics

  • 期刊论文

  • 发表日期：

    2025年7月12日

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  • Naveen Jeyaraman,
  • Madhan Jeyaraman,
  • Swaminathan Ramasubramanian,
  • Sathish Muthu,
  • Harish V. K. Ratna,
  • Sangeetha Balaji

摘要

Background

Bio-Active Composite Therapy (BACT) represents a significant advancement in regenerative orthopaedics, integrating bioactive materials with biological systems to enhance bone and tissue regeneration. This comprehensive approach leverages materials such as hydroxyapatite, bioactive glasses, polymers, and metals to create scaffolds that mimic the extracellular matrix, facilitating cellular activities essential for tissue repair.

Methods

A systematic literature review was conducted using databases including PubMed, Scopus, Web of Science, and Google Scholar. Keywords such as “Bio-Active Composite Therapy,” “regenerative orthopaedics,” and “bioactive materials” were employed to identify relevant studies published between 2000 and 2024. Inclusion criteria focused on peer-reviewed articles, reviews, and clinical trials related to the development, application, and evaluation of BACT in bone and soft tissue regeneration. Data extraction emphasized bioactive material types, fabrication techniques, clinical applications, outcomes, and associated challenges. The findings were categorized thematically to synthesize current advancements and identify knowledge gaps.

Results

BACT utilizes a diverse range of bioactive materials, with hydroxyapatite and bioactive glasses being predominant due to their osteoconductive and osteoinductive properties. Advanced fabrication techniques, particularly additive manufacturing (e.g., 3D printing), enable the creation of scaffolds with precise geometries and tailored porosity, enhancing cellular adhesion and proliferation. Clinically, BACT has demonstrated efficacy in bone regeneration, cartilage repair, and ligament healing, although biocompatibility and immunotoxicity remain challenges, especially with certain metal oxides like TiO₂. Economic barriers and technical precision in scaffold application also pose significant limitations.

Conclusion

BACT holds transformative potential in regenerative orthopaedics by offering tailored, effective treatments for musculoskeletal disorders. Overcoming biocompatibility, safety, and accessibility challenges through interdisciplinary collaboration and technological innovation is essential for its widespread clinical adoption. Future research should focus on optimizing bioactive materials and fabrication methods, alongside rigorous clinical trials to validate long-term efficacy and safety.

Graphical Abstract