<p>A series of novel multicellular square tubes (NMST) have been proposed through the evolution of traditional multicellular square tubes using various methods. The crashworthiness of these tubes, under consistent wall thickness conditions, has been assessed through numerical simulations utilizing validated models. The results indicate that the novel multicellular square tubes achieve significant improvements, with energy absorption (EA), specific energy absorption (SEA), and crush force efficiency (CFE) values that are 156.16%, 67.90%, and 53.50% higher, respectively, than those of traditional multicellular square tubes. An examination of the influence of wall thickness on the crashworthiness of the structures reveals that varying wall thickness enhances the energy absorption capabilities, with the most notable performance exhibited by the structure employing evolutionary strategy B. Furthermore, an investigation of different structures at equivalent mass demonstrates that the structure following evolutionary strategy D (NMSTD) displays the superior crashworthiness characteristics, while the structure adhering to evolutionary strategy E (NMSTE) exhibits relatively inferior crashworthiness. Specifically, the SEA of NMSTD is up to 67.29% greater, and the CFE is up to 47.69% higher in comparison to NMSTE. Lastly, a deformation pattern analysis and a theoretical analysis have also been conducted.</p>