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<p>Medicinal plants have long been used in traditional medicine to treat and prevent many diseases. The genus <i>Dipteryx,</i> Fabaceae, comprises 14 species in South and Central America, standing out for its diversity of compounds, such as coumarins, flavonoids, and terpenoids. This study aims to investigate the chemical constituents of <i>Dipteryx lacunifera</i> Ducke&#xa0;from Piauí State, Brazil, and to evaluate its cytotoxic, antimicrobial, and anticholinesterase activities. Five compounds were isolated from the hexane fraction derived from the ethanolic extract of the leaves: one steroid, β-sitosterol, two triterpenoids, lupeol and betulin and two sesquiterpenes, spathulenol, and (1a<i>R</i><sup><i>*</i></sup>,2'<i>R</i><sup><i>*</i></sup>,4a<i>R</i><sup><i>*</i></sup>,7<i>S</i><sup><i>*</i></sup>,7a<i>S</i><sup><i>*</i></sup>,7b<i>R</i><sup><i>*</i></sup>)-1,1,7-trimethyldecahydrospiro[cyclopropa[<i>e</i>]azulene-4,2'-oxiran]-7-ol. By GC–MS, 19 additional compounds were identified, such as hydrocarbons, steroids, diterpenes, and fatty acids. β-Sitosterol&#xa0;exhibited cytotoxic effects against BF-F10 and PC3 tumor cell lines. Regarding anticholinesterase activity, the hexane fraction demonstrated inhibition only at the highest concentration, while antimicrobial activity revealed efficacy against Gram-positive <i>Enterococcus faecalis</i> and <i>Staphylococcus aureus</i>. We report, for the first time, a rare sesquiterpene isolated from <i>D. lacunifera</i> leaves, highlighting its therapeutic potential and contributing to the scientific understanding of Piauí Cerrado biodiversity.</p> Graphical Abstract <p></p>

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Rare Sesquiterpene from Leaves of Dipteryx lacunifera and Evaluation of Biological Activities

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月15日

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  • Aline M. da Silva Duarte,
  • Rodrigo F. Santiago,
  • Evaldo S. Monção Filho,
  • Herbert Gonzaga Sousa,
  • João Paulo da S. Gomes,
  • Pedro V. O. S. Furtado,
  • Enedina Rodrigues da S. Neta,
  • Sidney G. de Lima,
  • Éverton L. de França Ferreira,
  • Gisele Santos de Araújo,
  • José Delano Barreto Marinho Filho,
  • Ana Jérsia Araújo,
  • Nathanael dos S. Alves,
  • Alyne R. de Araújo Nobre,
  • Mahendra Rai,
  • Mariana H. Chaves,
  • Gerardo Magela Vieira Júnior

摘要

Medicinal plants have long been used in traditional medicine to treat and prevent many diseases. The genus Dipteryx, Fabaceae, comprises 14 species in South and Central America, standing out for its diversity of compounds, such as coumarins, flavonoids, and terpenoids. This study aims to investigate the chemical constituents of Dipteryx lacunifera Ducke from Piauí State, Brazil, and to evaluate its cytotoxic, antimicrobial, and anticholinesterase activities. Five compounds were isolated from the hexane fraction derived from the ethanolic extract of the leaves: one steroid, β-sitosterol, two triterpenoids, lupeol and betulin and two sesquiterpenes, spathulenol, and (1aR*,2'R*,4aR*,7S*,7aS*,7bR*)-1,1,7-trimethyldecahydrospiro[cyclopropa[e]azulene-4,2'-oxiran]-7-ol. By GC–MS, 19 additional compounds were identified, such as hydrocarbons, steroids, diterpenes, and fatty acids. β-Sitosterol exhibited cytotoxic effects against BF-F10 and PC3 tumor cell lines. Regarding anticholinesterase activity, the hexane fraction demonstrated inhibition only at the highest concentration, while antimicrobial activity revealed efficacy against Gram-positive Enterococcus faecalis and Staphylococcus aureus. We report, for the first time, a rare sesquiterpene isolated from D. lacunifera leaves, highlighting its therapeutic potential and contributing to the scientific understanding of Piauí Cerrado biodiversity.

Graphical Abstract