Scholarlink

<p>Natural products represent an important source of bioactive compounds for drug discovery in anticancer research. Gum arabic, obtained from the plant species <i>Acacia senegal</i> (L.) Willd. (syn. of <i>Senegalia senegal</i> (L.) Britton), Fabaceae, has been reported to exhibit various biological activities; however, its molecular mechanisms in melanoma remain poorly understood. Paclitaxel is one of the most widely used chemotherapeutic agents, but the development of resistance and dose-limiting toxicities significantly restrict its clinical effectiveness. Therefore, this study investigated the effects of gum arabic, paclitaxel, and their combination on cell viability, proliferation, colony formation, apoptosis, and mitochondrial membrane potential in A2058 and SK-MEL-30 human melanoma cells. The results demonstrated that the combined treatment was more effective than single-agent treatments in suppressing cell viability, proliferation, and clonogenic capacity in both melanoma cell lines. The combination therapy significantly increased apoptotic cell death and induced a marked loss of mitochondrial membrane potential. Furthermore, the combined treatment increased Bax and caspase-9 protein expression while reducing Bcl-2 protein levels, indicating activation of the mitochondrial apoptotic pathway. These findings provide the first evidence that the combined use of gum arabic and paclitaxel induces apoptosis in human melanoma cells through mitochondrial pathway modulation, highlighting its potential as a novel combination strategy for melanoma treatment.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Gum Arabic Enhances Paclitaxel-Induced Apoptosis via Mitochondrial Membrane Potential Disruption in Melanoma Cells

  • 期刊论文

  • 发表日期：

    2026年5月27日

查看全文
  • Gulsah Evyapan,
  • Berna Ozdem,
  • Ibrahim Tekedereli

摘要

Natural products represent an important source of bioactive compounds for drug discovery in anticancer research. Gum arabic, obtained from the plant species Acacia senegal (L.) Willd. (syn. of Senegalia senegal (L.) Britton), Fabaceae, has been reported to exhibit various biological activities; however, its molecular mechanisms in melanoma remain poorly understood. Paclitaxel is one of the most widely used chemotherapeutic agents, but the development of resistance and dose-limiting toxicities significantly restrict its clinical effectiveness. Therefore, this study investigated the effects of gum arabic, paclitaxel, and their combination on cell viability, proliferation, colony formation, apoptosis, and mitochondrial membrane potential in A2058 and SK-MEL-30 human melanoma cells. The results demonstrated that the combined treatment was more effective than single-agent treatments in suppressing cell viability, proliferation, and clonogenic capacity in both melanoma cell lines. The combination therapy significantly increased apoptotic cell death and induced a marked loss of mitochondrial membrane potential. Furthermore, the combined treatment increased Bax and caspase-9 protein expression while reducing Bcl-2 protein levels, indicating activation of the mitochondrial apoptotic pathway. These findings provide the first evidence that the combined use of gum arabic and paclitaxel induces apoptosis in human melanoma cells through mitochondrial pathway modulation, highlighting its potential as a novel combination strategy for melanoma treatment.

Graphical Abstract