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<p>American trypanosomiasis is an important public health problem in Latin America. To date, the chemotherapeutic agents used to treat this disease have been unsatisfactory, underscoring the need to develop new, more effective pharmaceuticals. The nanoparticles have demonstrated an excellent drug delivery system that helps protect unstable metabolites such as allicin. As a first step, in this study was carried out the <i>in vitro</i> trypanocidal activity of <i>Allium sativum</i> L., Amaryllidaceae, allicin, and <i>A. sativum</i> and allicin encapsulated in TiO<sub>2</sub> and ZrO<sub>2</sub> nanoparticles against <i>Trypanosoma cruzi</i> epimastigote forms, as well as the <i>in vivo</i> trypanocidal activity in BALB/c mice in the acute phase of infection with <i>T. cruzi</i>. This is the first report of allicin and ZrO₂-allicin activity against <i>T. cruzi</i>, revealing the potential employment of the ZrO<sub>2</sub> nanoparticles to give advantages to metabolites as allicin.</p> Graphical Abstract <p></p>

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Antitrypanosomal Activity of Allium sativum and Allicin Encapsulated in TiO2 and ZrO2 Nanoparticles

  • 期刊论文

  • 发表日期：

    2026年5月5日

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  • Marlene Lariza Andrade Guel,
  • Glendy Marilú Polanco Hernández,
  • Lourdes Díaz Jiménez,
  • Dora Alicia Cortés Hernández,
  • Víctor Ermilo Arana Argáez,
  • Julio César Torres Romero,
  • Karla Guadalupe Fernández Martín,
  • Eugenia Guzmán Marín,
  • Karla Y. Acosta Viana

摘要

American trypanosomiasis is an important public health problem in Latin America. To date, the chemotherapeutic agents used to treat this disease have been unsatisfactory, underscoring the need to develop new, more effective pharmaceuticals. The nanoparticles have demonstrated an excellent drug delivery system that helps protect unstable metabolites such as allicin. As a first step, in this study was carried out the in vitro trypanocidal activity of Allium sativum L., Amaryllidaceae, allicin, and A. sativum and allicin encapsulated in TiO2 and ZrO2 nanoparticles against Trypanosoma cruzi epimastigote forms, as well as the in vivo trypanocidal activity in BALB/c mice in the acute phase of infection with T. cruzi. This is the first report of allicin and ZrO₂-allicin activity against T. cruzi, revealing the potential employment of the ZrO2 nanoparticles to give advantages to metabolites as allicin.

Graphical Abstract