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<p>There is a growing trend toward transforming industrial waste into sustainable, value-added products for health and wellness, such as cosmetics that promote the responsible reuse of industrial by-products. This study aimed to develop a photoprotective phytocosmetic nanoformulation using extracts obtained from red and white wine lees. Phytochemical analysis identified several flavonoids, including quercetin, in the extracts. The nanoemulsions formulated with red and white wine lees extracts exhibited nanometric droplet sizes of 242.9 ± 0.71&#xa0;nm and 225.5 ± 0.14&#xa0;nm, respectively. Transmission electron microscopy analysis confirmed the spherical morphology of the droplets in both nanoformulations. The <i>in vitro</i> sun protection factor value of the blank nanoemulsion was 19.14 ± 0.5, while the nanoemulsions containing red and white wine lees extracts showed sun protection factor values of 24.33 ± 0.6 and 24.45 ± 0.6, respectively, indicating a synergistic effect of the extracts on the sun protection factor efficacy of the chemical filters. The UVA/UVB ratio of the blank nanoformulation was 0.512 ± 0.5, but the nanoemulsions containing natural actives from red and white wine extracts increased the UVA/UVB ratio to 0.623 ± 0.6 and 0.601 ± 0.5, respectively, demonstrating good UVA protection. In addition, the formulations exhibited skin-compatible pH values (ranging from 4.5 to 5.2), effective occlusive properties that help prevent transepidermal water loss, and excellent spreadability, facilitating uniform application across the skin. Cytotoxicity assays using 3T3 fibroblast cell lines indicated no significant toxicity at the tested concentrations. The improved sun protection factor and UVA protection in the wine lees-based formulations may be attributed to the presence of UV-absorbing phytochemicals, while the antioxidant activity of phenolic compounds may provide additional protection against UV-induced oxidative stress. This approach aligns with ongoing research efforts aimed at environmental sustainability by transforming industrial waste into valuable resources, thereby enabling the development of innovative and eco-conscious cosmetic formulations.</p> Graphical abstract <p></p>

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Development of Phytocosmetic Photoprotective Nanoemulsion Containing Winery Industry Waste

  • 期刊论文

  • 发表日期：

    2025年10月18日

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  • Carina Sant’Anna Morgado,
  • Naomi Kato Simas,
  • Anne Caroline C. Gomes,
  • Dandara Alves Luz,
  • Ricardo Machado Kuster,
  • Mariana Sato de S. B. Monteiro,
  • Eduardo Ricci-Júnior

摘要

There is a growing trend toward transforming industrial waste into sustainable, value-added products for health and wellness, such as cosmetics that promote the responsible reuse of industrial by-products. This study aimed to develop a photoprotective phytocosmetic nanoformulation using extracts obtained from red and white wine lees. Phytochemical analysis identified several flavonoids, including quercetin, in the extracts. The nanoemulsions formulated with red and white wine lees extracts exhibited nanometric droplet sizes of 242.9 ± 0.71 nm and 225.5 ± 0.14 nm, respectively. Transmission electron microscopy analysis confirmed the spherical morphology of the droplets in both nanoformulations. The in vitro sun protection factor value of the blank nanoemulsion was 19.14 ± 0.5, while the nanoemulsions containing red and white wine lees extracts showed sun protection factor values of 24.33 ± 0.6 and 24.45 ± 0.6, respectively, indicating a synergistic effect of the extracts on the sun protection factor efficacy of the chemical filters. The UVA/UVB ratio of the blank nanoformulation was 0.512 ± 0.5, but the nanoemulsions containing natural actives from red and white wine extracts increased the UVA/UVB ratio to 0.623 ± 0.6 and 0.601 ± 0.5, respectively, demonstrating good UVA protection. In addition, the formulations exhibited skin-compatible pH values (ranging from 4.5 to 5.2), effective occlusive properties that help prevent transepidermal water loss, and excellent spreadability, facilitating uniform application across the skin. Cytotoxicity assays using 3T3 fibroblast cell lines indicated no significant toxicity at the tested concentrations. The improved sun protection factor and UVA protection in the wine lees-based formulations may be attributed to the presence of UV-absorbing phytochemicals, while the antioxidant activity of phenolic compounds may provide additional protection against UV-induced oxidative stress. This approach aligns with ongoing research efforts aimed at environmental sustainability by transforming industrial waste into valuable resources, thereby enabling the development of innovative and eco-conscious cosmetic formulations.

Graphical abstract