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<p>Diabetes, a metabolic syndrome, is on the rise and is attributed to a sedentary lifestyle, high levels of professional stress, obesity, and a lack of physical activity. Medicinal plants are emerging as novel therapeutic agents for the management of various metabolic disorders, most notably hyperglycemia. The PubMed, Scopus, Scholar, and Science Direct databases were employed to conduct a comprehensive search and collect pertinent articles. The authors adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines while preparing the systematic reviews. A total of 5119 papers were initially gathered through an electronic database search for this narrative review. Analysis of <i>in vivo</i> studies has documented that medicinal plant extracts exert their anti-diabetic effects through various mechanisms, such as enhancing the release of insulin from pancreatic β-cells, increasing the binding of insulin to receptors, reducing insulin resistance, and improving glucose tolerance. Other modes of action include increasing glucose metabolism, enhancing function of β-cells, and elevating plasma insulin levels, which results in a decrease in circulating blood glucose levels. Therefore, this comprehensive review focuses on <i>in vivo</i> studies and examines medicinal plant extracts that have undergone scientific testing in clinical trials. Furthermore, the study provides an insightful examination of the pathophysiology and etiology of type 2 diabetes mellitus. Based on <i>in vivo</i> investigations and clinical trials, medicinal plant extracts show significant promise for future development as innovative drugs or therapies to treat type 2 diabetes mellitus and its associated complications.</p> Graphical Abstract <p></p>

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A Systematic Assessment of the Plausible Role of Herbal Plants in Diabetes Mellitus

  • 期刊论文

  • 发表日期：

    2025年8月7日

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  • Neeraj Choudhary,
  • Gurinder Kaur Dhaliwal,
  • Puneet Kaur,
  • Ujjwal Kaushik,
  • Vikrant Abbot,
  • Rakesh Kumar,
  • Shubham Kumar,
  • Sukhpreet Singh

摘要

Diabetes, a metabolic syndrome, is on the rise and is attributed to a sedentary lifestyle, high levels of professional stress, obesity, and a lack of physical activity. Medicinal plants are emerging as novel therapeutic agents for the management of various metabolic disorders, most notably hyperglycemia. The PubMed, Scopus, Scholar, and Science Direct databases were employed to conduct a comprehensive search and collect pertinent articles. The authors adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines while preparing the systematic reviews. A total of 5119 papers were initially gathered through an electronic database search for this narrative review. Analysis of in vivo studies has documented that medicinal plant extracts exert their anti-diabetic effects through various mechanisms, such as enhancing the release of insulin from pancreatic β-cells, increasing the binding of insulin to receptors, reducing insulin resistance, and improving glucose tolerance. Other modes of action include increasing glucose metabolism, enhancing function of β-cells, and elevating plasma insulin levels, which results in a decrease in circulating blood glucose levels. Therefore, this comprehensive review focuses on in vivo studies and examines medicinal plant extracts that have undergone scientific testing in clinical trials. Furthermore, the study provides an insightful examination of the pathophysiology and etiology of type 2 diabetes mellitus. Based on in vivo investigations and clinical trials, medicinal plant extracts show significant promise for future development as innovative drugs or therapies to treat type 2 diabetes mellitus and its associated complications.

Graphical Abstract