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<p>As a characteristic ethnic medicine in Guizhou, China, the roots and stems of <i>Sabia parviflora</i> Wall., Sabiaceae, are traditionally used by ethnic minorities such as the Buyi and Miao to treat hepatitis, rheumatoid arthritis, and other diseases. However, harvesting roots is not conducive to the sustainable utilization of <i>S. parviflora</i> resources. In this study, ultraviolet–visible spectrophotometry and high-performance liquid chromatography were employed to quantitatively determine the contents of total flavonoids, total saponins, and seven specific flavonoid compounds in different medicinal parts of <i>S. parviflora</i>, as well as in leaves collected during different harvesting times. Additionally, a lipopolysaccharide-induced RAW264.7 cell inflammation model was established, and the concentration levels of NO, IL-6, and TNF-α were measured to evaluate the anti-inflammatory effects of six monomeric components extracted from <i>S. parviflora</i>. The results indicated that total saponins and flavonoid components were primarily enriched in the leaves of <i>S. parviflora</i>, and the optimal harvest time for the leaves was determined to be from February to April. The anti-inflammatory activity assay demonstrated that the six monomeric components significantly reduced the concentrations of NO, IL-6, and TNF-α in a dose-dependent manner. These findings provide a theoretical basis for further research into the pharmacological effects of <i>S. parviflora</i> and the development of anti-inflammatory drugs.</p> Graphical Abstract <p></p>

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Distribution, Accumulation of Sabia parviflora Active Components, and Anti-inflammatory Activity of Flavonoids Monomer

  • 期刊论文

  • 发表日期：

    2025年7月28日

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  • Mingyang Zhou,
  • Jingzhong Chen,
  • Zhanchi Xu,
  • Guoji Pan,
  • Jian Wang,
  • Haibing Qian,
  • Qingwen Sun

摘要

As a characteristic ethnic medicine in Guizhou, China, the roots and stems of Sabia parviflora Wall., Sabiaceae, are traditionally used by ethnic minorities such as the Buyi and Miao to treat hepatitis, rheumatoid arthritis, and other diseases. However, harvesting roots is not conducive to the sustainable utilization of S. parviflora resources. In this study, ultraviolet–visible spectrophotometry and high-performance liquid chromatography were employed to quantitatively determine the contents of total flavonoids, total saponins, and seven specific flavonoid compounds in different medicinal parts of S. parviflora, as well as in leaves collected during different harvesting times. Additionally, a lipopolysaccharide-induced RAW264.7 cell inflammation model was established, and the concentration levels of NO, IL-6, and TNF-α were measured to evaluate the anti-inflammatory effects of six monomeric components extracted from S. parviflora. The results indicated that total saponins and flavonoid components were primarily enriched in the leaves of S. parviflora, and the optimal harvest time for the leaves was determined to be from February to April. The anti-inflammatory activity assay demonstrated that the six monomeric components significantly reduced the concentrations of NO, IL-6, and TNF-α in a dose-dependent manner. These findings provide a theoretical basis for further research into the pharmacological effects of S. parviflora and the development of anti-inflammatory drugs.

Graphical Abstract