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<p>In the present study, we have designed and evaluated the antibacterial efficacy of stearic acid ester derivative of sesamol, a phenolic compound found in sesame seeds, against <i>Mycoplasma pneumoniae</i>–induced pneumonia in mice. The synthesis of stearic acid ester derivative of sesamol was achieved in a facile synthetic route with excellent yield. The molecule was tested for <i>in vitro</i> antibacterial activity against <i>M. pneumoniae</i> and pharmacological activity in <i>M. pneumoniae</i>–induced pneumonia in mice and various biochemical parameters were observed. Stearic acid ester derivative of sesamol showed significant <i>in vitro</i> antibacterial activity and improved the level of NO, and myeloperoxidase including the lung weight index near to control in a dose-dependent manner in experimental animals. The levels of GSH and SOD were found significantly increased with a reduction in MDA activity as compared to pneumonia-induced mice. The level of pro-inflammatory cytokines, such as IL-6, IL-1β, and TNF-α, and total cells and DNA content were also found reduced in stearic acid ester derivative of the sesamol-treated group as compared to disease control mice. In western blot analysis, stearic acid ester derivative of sesamol-treated rats showed a reduction of activation of NF-κB, and the highest activity was achieved in the case of mice treated with 20&#xa0;mg/kg dose. Our study demonstrated that conjugation of fatty acid increases the pharmacological activity of sesamol and the resulting product stearic acid ester derivative of sesamol possesses significant antibacterial activity against <i>M. pneumoniae</i> infection. It also showed antioxidant and anti-inflammatory activity. This study is the first report of its sort to explore the antibacterial potential of the stearic acid derivative of sesamol.</p> Graphical Abstract <p></p>

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RETRACTED ARTICLE: Derivatization of Sesamol with Stearic Acid Enhances Antibacterial Activity Against Mycoplasma pneumoniae–Induced Pneumonia in Mice

  • 期刊论文

  • 发表日期：

    2025年4月23日

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  • Zeliang Yin,
  • Lishuo Guo,
  • Qinhua Xu,
  • Ziliang Liu,
  • Hang Jia,
  • Qianya Ye

摘要

In the present study, we have designed and evaluated the antibacterial efficacy of stearic acid ester derivative of sesamol, a phenolic compound found in sesame seeds, against Mycoplasma pneumoniae–induced pneumonia in mice. The synthesis of stearic acid ester derivative of sesamol was achieved in a facile synthetic route with excellent yield. The molecule was tested for in vitro antibacterial activity against M. pneumoniae and pharmacological activity in M. pneumoniae–induced pneumonia in mice and various biochemical parameters were observed. Stearic acid ester derivative of sesamol showed significant in vitro antibacterial activity and improved the level of NO, and myeloperoxidase including the lung weight index near to control in a dose-dependent manner in experimental animals. The levels of GSH and SOD were found significantly increased with a reduction in MDA activity as compared to pneumonia-induced mice. The level of pro-inflammatory cytokines, such as IL-6, IL-1β, and TNF-α, and total cells and DNA content were also found reduced in stearic acid ester derivative of the sesamol-treated group as compared to disease control mice. In western blot analysis, stearic acid ester derivative of sesamol-treated rats showed a reduction of activation of NF-κB, and the highest activity was achieved in the case of mice treated with 20 mg/kg dose. Our study demonstrated that conjugation of fatty acid increases the pharmacological activity of sesamol and the resulting product stearic acid ester derivative of sesamol possesses significant antibacterial activity against M. pneumoniae infection. It also showed antioxidant and anti-inflammatory activity. This study is the first report of its sort to explore the antibacterial potential of the stearic acid derivative of sesamol.

Graphical Abstract