Scholarlink

Purpose <p>Adult spinal deformity (ASD) is a chronic musculoskeletal condition characterized by abnormal spinal curvature and adverse psychological well-being. However, the mental health burden of ASD remains poorly characterized. This retrospective cross-sectional cohort study compared the prevalence and odds of mental health conditions in the ASD population to a matched general population cohort using the nationally representative All of Us Research Program.</p> Methods <p>ASD patients (n = 6531) were identified using ICD-9/10. Using 1:1 nearest neighbor propensity matching without replacement (caliper = 0.05), 6396 ASD patients were matched to 6396 general population controls. Logistic regression was performed to compute odds ratios (OR) and 95% confidence-intervals (CI) for mental health outcomes.</p> Results <p>After matching, mean age was 58.0 and 76% were female. Compared to the general population, ASD patients had higher unadjusted rates of depression (37.6% vs. 11.3%), anxiety (41.6% vs. 12.1%), post-traumatic stress disorder (PTSD) (7.2% vs. 2.2%), bipolar disorder (7.1% vs. 2.1%), schizophrenia/psychosis (2.4% vs. 0.9%), substance use disorders (24.3% vs. 9.7%), eating disorders (1.4% vs. 0.4%), and attention-deficit hyperactivity disorder (ADHD) (5.3% vs. 1.4%). On logistic regression, ASD patients had higher odds of depression (OR = 2.06, CI = 1.90–2.23, <i>P</i> &lt; 0.001), anxiety (OR = 2.24, CI = 2.07–2.43, <i>P</i> &lt; 0.001), and ADHD (OR = 2.87, CI = 2.32–3.54, <i>P</i> &lt; 0.001). ASD patients also exhibited significantly elevated odds for eating disorders, bipolar disorder, PTSD, and substance use disorder (<i>P</i> &lt; 0.05).</p> Conclusions <p>ASD patients in the United States have a substantially elevated mental health burden than the general populace. Routine mental health screenings and psychological assessments can be beneficial for this vulnerable population.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

National mental health burden in adults with spinal deformity: a propensity-matched analysis using the All of Us Research Program

  • 期刊论文

  • 发表日期：

    2025年12月17日

查看全文
  • Tanmay S. Mehta,
  • Manjot Singh,
  • Michael J. Farias,
  • Joseph E. Nassar,
  • Nicolas L. Carayannopoulos,
  • Zvipo M. Chisango,
  • Alan H. Daniels,
  • Bassel G. Diebo

摘要

Purpose

Adult spinal deformity (ASD) is a chronic musculoskeletal condition characterized by abnormal spinal curvature and adverse psychological well-being. However, the mental health burden of ASD remains poorly characterized. This retrospective cross-sectional cohort study compared the prevalence and odds of mental health conditions in the ASD population to a matched general population cohort using the nationally representative All of Us Research Program.

Methods

ASD patients (n = 6531) were identified using ICD-9/10. Using 1:1 nearest neighbor propensity matching without replacement (caliper = 0.05), 6396 ASD patients were matched to 6396 general population controls. Logistic regression was performed to compute odds ratios (OR) and 95% confidence-intervals (CI) for mental health outcomes.

Results

After matching, mean age was 58.0 and 76% were female. Compared to the general population, ASD patients had higher unadjusted rates of depression (37.6% vs. 11.3%), anxiety (41.6% vs. 12.1%), post-traumatic stress disorder (PTSD) (7.2% vs. 2.2%), bipolar disorder (7.1% vs. 2.1%), schizophrenia/psychosis (2.4% vs. 0.9%), substance use disorders (24.3% vs. 9.7%), eating disorders (1.4% vs. 0.4%), and attention-deficit hyperactivity disorder (ADHD) (5.3% vs. 1.4%). On logistic regression, ASD patients had higher odds of depression (OR = 2.06, CI = 1.90–2.23, P < 0.001), anxiety (OR = 2.24, CI = 2.07–2.43, P < 0.001), and ADHD (OR = 2.87, CI = 2.32–3.54, P < 0.001). ASD patients also exhibited significantly elevated odds for eating disorders, bipolar disorder, PTSD, and substance use disorder (P < 0.05).

Conclusions

ASD patients in the United States have a substantially elevated mental health burden than the general populace. Routine mental health screenings and psychological assessments can be beneficial for this vulnerable population.