Scholarlink

Purpose <p>Vertebral body tethering (VBT) is a non-fusion surgical option for adolescent idiopathic scoliosis (AIS) that requires a postoperative (PO) chest tube. This study evaluates whether 48&#xa0;h of PO TXA reduces chest tube (CT) drainage and retention compared to 24&#xa0;h of TXA following VBT for AIS.</p> Methods <p>Consecutively treated patients with a diagnosis of AIS who underwent VBT were assessed. Thirty-eight patients who received 48&#xa0;h of PO IV TXA (48-TXA) were compared to 35 VBT patients who received 24&#xa0;h of PO IV TXA (24-TXA) and 48 patients who did not receive TXA (non-TXA). TXA use in thoracic CT and thoracolumbar CT drainages were also assessed separately. Group comparisons were performed using one-way ANOVA and Chi-square tests<i>.</i></p> Results <p>There were no significant differences in demographics between groups. TXA significantly reduced CT drainage (<i>p</i> &lt; 0.001) and retention (<i>p</i> &lt; 0.001), with no differences between 24-TXA and 48-TXA (<i>p</i> = 0.88). Sub-analyses showed that both 24-TXA and 48-TXA reduced thoracic CT drainage (<i>p</i> = 0.002, <i>p</i> = 0.02) and retention time (<i>p</i> = 0.04, <i>p</i> = 0.007) compared to non-TXA, respectively. For thoracolumbar CT, differences were observed only between 24-TXA and non-TXA (<i>p</i> = 0.01, <i>p</i> = 0.03). TXA was an independent predictor of reduced CT drainage (<i>p</i> &lt; 0.001) and retention (<i>p</i> &lt; 0.001). Hospital stay, ICU stay, and complications didn’t differ between TXA groups (<i>p</i> &gt; 0.9, <i>p</i> = 0.4), respectively.</p> Conclusions <p>Intravenous TXA reduces CT drainage and retention after VBT for AIS for thoracic CTs. There was no additional benefit of 48-TXA over 24-TXA in decreasing overall drainage and CT retention time.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Reducing postoperative morbidity by diminishing chest tube drainage utilizing tranexamic acid following vertebral body tethering for adolescent idiopathic scoliosis

  • 期刊论文

  • 发表日期：

    2025年1月26日

查看全文
  • Rami Rajjoub,
  • Mark Kurapatti,
  • Mateo Restrepo Mejia,
  • Olgerta Mucollari,
  • Rodnell Busigó Torres,
  • Husni Alasadi,
  • Baron S. Lonner

摘要

Purpose

Vertebral body tethering (VBT) is a non-fusion surgical option for adolescent idiopathic scoliosis (AIS) that requires a postoperative (PO) chest tube. This study evaluates whether 48 h of PO TXA reduces chest tube (CT) drainage and retention compared to 24 h of TXA following VBT for AIS.

Methods

Consecutively treated patients with a diagnosis of AIS who underwent VBT were assessed. Thirty-eight patients who received 48 h of PO IV TXA (48-TXA) were compared to 35 VBT patients who received 24 h of PO IV TXA (24-TXA) and 48 patients who did not receive TXA (non-TXA). TXA use in thoracic CT and thoracolumbar CT drainages were also assessed separately. Group comparisons were performed using one-way ANOVA and Chi-square tests.

Results

There were no significant differences in demographics between groups. TXA significantly reduced CT drainage (p < 0.001) and retention (p < 0.001), with no differences between 24-TXA and 48-TXA (p = 0.88). Sub-analyses showed that both 24-TXA and 48-TXA reduced thoracic CT drainage (p = 0.002, p = 0.02) and retention time (p = 0.04, p = 0.007) compared to non-TXA, respectively. For thoracolumbar CT, differences were observed only between 24-TXA and non-TXA (p = 0.01, p = 0.03). TXA was an independent predictor of reduced CT drainage (p < 0.001) and retention (p < 0.001). Hospital stay, ICU stay, and complications didn’t differ between TXA groups (p > 0.9, p = 0.4), respectively.

Conclusions

Intravenous TXA reduces CT drainage and retention after VBT for AIS for thoracic CTs. There was no additional benefit of 48-TXA over 24-TXA in decreasing overall drainage and CT retention time.