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<p><i>Athenaea velutina</i> (Sendtn.) D’Arcy, a native plant of the Brazilian Atlantic Forest, has exhibited potential pharmacological effects due to the presence of withanolides with anti-cancer and anti-inflammatory activities. However, there is a lack of research on the safety and toxicity of this plant species. This study aimed to assess the safety of the ethanolic extract of <i>A. velutina</i> leaves (Av-E) through toxicity and phytochemical analysis. Acute [1000&#xa0;mg kg<sup>−1</sup> body weight (BW)] and subacute (250, 500, and 1000&#xa0;mg kg<sup>−1</sup> BW) toxicity tests were conducted on female Wistar rats, along with an evaluation of the toxic reversal effect. HPLC-HRMS revealed the presence of withanolide steroids in Av-E. Reduced alanine aminotransferase (ALT), bilirubin levels, and increased calcium concentrations were observed after the acute toxicity test. Subacute toxicity demonstrated lowered ALT (250 and 1000&#xa0;mg kg<sup>−1</sup> BW) and aspartate aminotransferase (AST) (250 and 500&#xa0;mg kg<sup>−1</sup> BW) levels and increased sodium concentration (250&#xa0;mg kg<sup>−1</sup> BW). No fatalities or clinical signs of toxicity occurred, and histological and biochemical analysis revealed no apparent liver or kidney toxicity. In conclusion, Av-E exhibited no toxicity in the experiments, encouraging further research to develop new herbal medicines.</p>

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Exploring the safety parameters of Athenaea velutina ethanolic extract: a step towards harnessing its medicinal potential

  • 期刊论文

  • 发表日期：

    2025年1月13日

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  • Jordana Luizi dos Prazeres,
  • Alisson Andrade Almeida,
  • Renner Philipe Rodrigues Carvalho,
  • Luiz Carlos Maia Ladeira,
  • Luiz Pedro de Souza Costa,
  • Markus Kohlhoff,
  • Leandro Licursi de Oliveira,
  • Mariana Machado-Neves,
  • João Paulo Viana Leite

摘要

Athenaea velutina (Sendtn.) D’Arcy, a native plant of the Brazilian Atlantic Forest, has exhibited potential pharmacological effects due to the presence of withanolides with anti-cancer and anti-inflammatory activities. However, there is a lack of research on the safety and toxicity of this plant species. This study aimed to assess the safety of the ethanolic extract of A. velutina leaves (Av-E) through toxicity and phytochemical analysis. Acute [1000 mg kg−1 body weight (BW)] and subacute (250, 500, and 1000 mg kg−1 BW) toxicity tests were conducted on female Wistar rats, along with an evaluation of the toxic reversal effect. HPLC-HRMS revealed the presence of withanolide steroids in Av-E. Reduced alanine aminotransferase (ALT), bilirubin levels, and increased calcium concentrations were observed after the acute toxicity test. Subacute toxicity demonstrated lowered ALT (250 and 1000 mg kg−1 BW) and aspartate aminotransferase (AST) (250 and 500 mg kg−1 BW) levels and increased sodium concentration (250 mg kg−1 BW). No fatalities or clinical signs of toxicity occurred, and histological and biochemical analysis revealed no apparent liver or kidney toxicity. In conclusion, Av-E exhibited no toxicity in the experiments, encouraging further research to develop new herbal medicines.