Scholarlink

Purpose <p>This study aimed to evaluate the effect of platelet-rich plasma (PRP) on sperm motility in men with asthenozoospermia and assess its potential use in intrauterine insemination (IUI).</p> Materials and methods <p>A prospective randomized controlled pilot study was conducted with 40 men diagnosed with asthenozoospermia. Semen samples were divided into two equal parts: one treated with autologous, non-activated PRP and the other serving as control. Sperm motility was assessed at 1, 3, 6, and 24&#xa0;h using a Makler chamber. A two-step centrifugation method was used for PRP preparation, and all samples underwent identical swim-up protocols. Data were analyzed using two-way repeated measures ANOVA.</p> Results <p>PRP-treated samples showed significantly higher motility than controls at all time points (<i>p</i> &lt; 0.001). PRP also slowed the decline in motility over time. At 24&#xa0;h, motility was 50.5% in the PRP group versus 21.1% in controls. Statistical analysis confirmed normal data distribution.</p> Conclusion <p>PRP significantly enhances and preserves sperm motility during in vitro incubation. These findings suggest that PRP may serve as a supportive option in sperm preparation for IUI, potentially reducing the need for more invasive techniques. Further studies are warranted to evaluate clinical outcomes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Towards Better Assisted Reproductive Techniques Outcomes: Using Platelet-Rich Plasma to Improve Sperm Motility

  • 期刊论文

  • 发表日期：

    2025年10月30日

查看全文
  • Serhat Yentur,
  • Yunus Emre Dusunus,
  • Ibrahim Ogulcan Canitez,
  • Gokhan Cil,
  • Aykut Colakerol,
  • Ismail Engin Kandirali

摘要

Purpose

This study aimed to evaluate the effect of platelet-rich plasma (PRP) on sperm motility in men with asthenozoospermia and assess its potential use in intrauterine insemination (IUI).

Materials and methods

A prospective randomized controlled pilot study was conducted with 40 men diagnosed with asthenozoospermia. Semen samples were divided into two equal parts: one treated with autologous, non-activated PRP and the other serving as control. Sperm motility was assessed at 1, 3, 6, and 24 h using a Makler chamber. A two-step centrifugation method was used for PRP preparation, and all samples underwent identical swim-up protocols. Data were analyzed using two-way repeated measures ANOVA.

Results

PRP-treated samples showed significantly higher motility than controls at all time points (p < 0.001). PRP also slowed the decline in motility over time. At 24 h, motility was 50.5% in the PRP group versus 21.1% in controls. Statistical analysis confirmed normal data distribution.

Conclusion

PRP significantly enhances and preserves sperm motility during in vitro incubation. These findings suggest that PRP may serve as a supportive option in sperm preparation for IUI, potentially reducing the need for more invasive techniques. Further studies are warranted to evaluate clinical outcomes.