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<p>This research delves into the association of Kisspeptin and the <i>KISS</i><sub>1</sub> gene (rs35431622) single nucleotide polymorphism with circulating sex hormones and semen parameters in males diagnosed with infertility. Eighty male participants were recruited from fertility clinic, were divided into two groups: Group A, characterized by normal sperm count and Group B, exhibiting low count. The analysis involved assessing hormone levels Kisspeptin, follicle stimulating hormone, luteinizing hormone, total testosterone and sex hormone binding globulin by utilizing ELISA, investigating the association of the <i>KISS</i><sub>1</sub> gene SNP with these variables through Tetra amplification refractory mutation system-PCR and Gel Electrophoresis. The findings revealed that males a low sperm count displayed notably reduced levels of Kisspeptin and free testosterone, accompanied by increased luteinizing hormone and follicle stimulating hormone. The <i>KISS</i><sub>1</sub> gene SNP rs35431622 (Q36R) demonstrated a 53.3% frequency of the heterozygous mutant TA genotype and OR 0.19 (CI 0.05–0.71) among infertile males, indicating its potential implications a risk factor for male infertility. This study emphasizes the significance of Kisspeptin in overseeing male reproductive health and highlights its potential as a marker for hormonal dysregulation in male infertility.</p>

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Association of Kisspeptin and KISS1 Gene Polymorphism (rs35431622) with Circulating Sex Hormones and Male Infertility

  • 期刊论文

  • 发表日期：

    2025年2月5日

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  • N. Prasath,
  • K. A. Arul Senghor,
  • V. M. Vinodhini,
  • M. Anuradha

摘要

This research delves into the association of Kisspeptin and the KISS1 gene (rs35431622) single nucleotide polymorphism with circulating sex hormones and semen parameters in males diagnosed with infertility. Eighty male participants were recruited from fertility clinic, were divided into two groups: Group A, characterized by normal sperm count and Group B, exhibiting low count. The analysis involved assessing hormone levels Kisspeptin, follicle stimulating hormone, luteinizing hormone, total testosterone and sex hormone binding globulin by utilizing ELISA, investigating the association of the KISS1 gene SNP with these variables through Tetra amplification refractory mutation system-PCR and Gel Electrophoresis. The findings revealed that males a low sperm count displayed notably reduced levels of Kisspeptin and free testosterone, accompanied by increased luteinizing hormone and follicle stimulating hormone. The KISS1 gene SNP rs35431622 (Q36R) demonstrated a 53.3% frequency of the heterozygous mutant TA genotype and OR 0.19 (CI 0.05–0.71) among infertile males, indicating its potential implications a risk factor for male infertility. This study emphasizes the significance of Kisspeptin in overseeing male reproductive health and highlights its potential as a marker for hormonal dysregulation in male infertility.