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<p>Eleven nardosinane-type compounds, including a norsesquiterpenoid featuring a novel carbon skeleton designated as paralemnanoid A (<b>1</b>), and ten additional norsesquiterpenoids identified as paralemnanoids B − K (<b>2</b> − <b>11</b>), were isolated from the South China Sea soft coral <i>Paralemnalia</i> sp.. Comprehensive structural elucidation of compounds <b>1</b> − <b>11</b> was achieved through an integrated analytical approach, combining including NMR spectroscopy, HRESIMS, single-crystal X-ray diffraction analysis, DP4 + probability assessments, ECD calculations, and literature comparisons. Furthermore, we proposed that the novel poly-isoprenoid scaffold paralemnanoid A (<b>1</b>) originates from paralemnanoid B (<b>2</b>) through sequential oxidative modifications followed by non-enzymatic skeletal rearrangements. The hepatoprotective effects of compounds <b>1</b> − <b>11</b> were assessed through bioassays, revealing that paralemnanoids A (<b>1</b>) and E (<b>5</b>) exhibited moderate hepatoprotective activity at a concentration of 20&#xa0;μmol/L in the zebrafish model. This study expands the chemical diversity of marine-derived nardosinane-type terpenoids and provides new insights into their potential therapeutic applications.</p>

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Paralemnanoids A–K, new norsesquiterpenoids and sesquiterpenoids with hepatoprotective activity from the soft coral Paralemnalia sp.

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月30日

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  • Yanfang Pei,
  • Yuan Zong,
  • Jixiang Xu,
  • Huiyue Hou,
  • Hengyi Xu,
  • Yun Chen,
  • Tianyun Jin,
  • Pinglin Li

摘要

Eleven nardosinane-type compounds, including a norsesquiterpenoid featuring a novel carbon skeleton designated as paralemnanoid A (1), and ten additional norsesquiterpenoids identified as paralemnanoids B − K (2 − 11), were isolated from the South China Sea soft coral Paralemnalia sp.. Comprehensive structural elucidation of compounds 1 − 11 was achieved through an integrated analytical approach, combining including NMR spectroscopy, HRESIMS, single-crystal X-ray diffraction analysis, DP4 + probability assessments, ECD calculations, and literature comparisons. Furthermore, we proposed that the novel poly-isoprenoid scaffold paralemnanoid A (1) originates from paralemnanoid B (2) through sequential oxidative modifications followed by non-enzymatic skeletal rearrangements. The hepatoprotective effects of compounds 1 − 11 were assessed through bioassays, revealing that paralemnanoids A (1) and E (5) exhibited moderate hepatoprotective activity at a concentration of 20 μmol/L in the zebrafish model. This study expands the chemical diversity of marine-derived nardosinane-type terpenoids and provides new insights into their potential therapeutic applications.