<p>Autism Spectrum Disorder (ASD) is a brain-based condition characterized by social difficulties and repetitive behaviors. Traditional diagnostic methods can be subjective and time-consuming. Current diagnostic techniques for ASD often rely on behavioral assessments and clinical observations, which can be inconsistent and prone to subjectivity. Additionally, there is a need for more reliable and objective methods to differentiate between autistic and non-autistic individuals. Existing imaging techniques require further refinement to improve accuracy and efficiency in detecting ASD. The primary objective of this research is to develop and evaluate an enhanced detection system for ASD using thermal imaging and Improved Mask Faster Recurrent Convolutional Neural Network (IMFRCNN). This research focuses on enhancing the detection of ASD using Deep Learning (DL) methods and thermal imaging. Traditional diagnostic techniques for ASD often rely on subjective behavioral assessments, highlighting the need for more reliable methods. By examining cerebral imaging data from the thermal face image datasets collect facial thermal images using thermal cameras. Ensure the dataset is diverse, including varying expressions and environmental conditions. The study compares the effectiveness of IMFRCNN and the ResNet 50 system in classifying thermal images of 50 autistic and 50 non-autistic individuals. Emotions were evoked using audio-visual stimuli, and temperature variations in facial areas such as the nose, forehead, cheek, and eyes were measured. Anger showed the greatest temperature differences, with a 12.6% variation between autistic and non-autistic individuals. The IMFRCNN achieved a reliability of 96%, while the ResNet 50 achieved 90%. These findings indicate that computer-aided assessment techniques utilizing thermal imaging and DL can provide a consistent and objective method for identifying individuals with ASD.</p>