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Background <p>It is unknown whether an appropriate amount of exogenous antioxidant intake is present to maximize the exercise benefit on lifestyle-related diseases. The purpose of this study was to investigate the effects of two levels of exercise stress and exogenous antioxidant doses on exercise-induced oxidative stress, antioxidant capacity, and inflammatory response.</p> Methods <p>Wistar male rats were divided into two groups; sedentary (SED) and exercise (TR). The exercise was increased from 4&#xa0;weeks of lower-load (90&#xa0;min/week) to 4&#xa0;weeks of higher-load (300&#xa0;min/week). TR was subdivided into low (70&#xa0;mg/kg: TR + N), medium (350&#xa0;mg/kg: TR + VE-M), and high (700&#xa0;mg/kg: TR + VE-H) according to the amount of vitamin E intake. Oxidative stress (d-ROMs), antioxidative capacity (BAP), and inflammatory response (hs-CRP: high sensitive C-reactive protein) were measured with blood samples before and after each exercise load PGC1-<i>α</i> was measured with muscle samples using real-time PCR.</p> Results <p>d-ROMs increased as exercise load was augmented in all TR and was higher in TR + N and TR + VE-M than in SED after higher-load exercise, while it was not different between SED and TR + VE-H. hs-CRP increased in TR + N and TR + VE-H after higher-load exercise as compared with before. PGC1-<i>α</i> increased only in TR + VE-M after higher-load exercise. CONCLUSIONSː Only medium doses of vitamin E intake may suppress the inflammatory response to oxidative stress during a large amount of exercise without inhibiting the expression of the transcription factor PGC1-<i>α</i>, suggesting the presence of an appropriate dose for exogenous antioxidant intake during exercise.</p>

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Effects of Different Doses of Antioxidant Intake on Exercise-Induced Oxidative Stress, Antioxidative Capacity and Inflammatory Responses

  • 期刊论文

  • 发表日期：

    2026年2月9日

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  • Rina Suzuki,
  • Akiko Yamaki,
  • Hiroyasu Murata,
  • Kazukuni Hirabuki,
  • Noritaka Hata,
  • Ai Hirasawa,
  • Ken Muramatsu,
  • Takeaki Matsuda,
  • Shigeki Shibata

摘要

Background

It is unknown whether an appropriate amount of exogenous antioxidant intake is present to maximize the exercise benefit on lifestyle-related diseases. The purpose of this study was to investigate the effects of two levels of exercise stress and exogenous antioxidant doses on exercise-induced oxidative stress, antioxidant capacity, and inflammatory response.

Methods

Wistar male rats were divided into two groups; sedentary (SED) and exercise (TR). The exercise was increased from 4 weeks of lower-load (90 min/week) to 4 weeks of higher-load (300 min/week). TR was subdivided into low (70 mg/kg: TR + N), medium (350 mg/kg: TR + VE-M), and high (700 mg/kg: TR + VE-H) according to the amount of vitamin E intake. Oxidative stress (d-ROMs), antioxidative capacity (BAP), and inflammatory response (hs-CRP: high sensitive C-reactive protein) were measured with blood samples before and after each exercise load PGC1-α was measured with muscle samples using real-time PCR.

Results

d-ROMs increased as exercise load was augmented in all TR and was higher in TR + N and TR + VE-M than in SED after higher-load exercise, while it was not different between SED and TR + VE-H. hs-CRP increased in TR + N and TR + VE-H after higher-load exercise as compared with before. PGC1-α increased only in TR + VE-M after higher-load exercise. CONCLUSIONSː Only medium doses of vitamin E intake may suppress the inflammatory response to oxidative stress during a large amount of exercise without inhibiting the expression of the transcription factor PGC1-α, suggesting the presence of an appropriate dose for exogenous antioxidant intake during exercise.