Scholarlink

<p>Regular physical activity clearly exerts numerous positive effects on cognitive function. We verified the impact of resistance training (RT) and concurrent training (CT) on cognitive function in mice, as well as the expression of cognition-related genes and brain-specific miRNAs in the hippocampus. In this study, it was demonstrated that RT and CT led to a decrease in <i>miR-21</i> and <i>miR-132</i> levels in the hippocampus of mice, and improved their spatial memory ability. The levels of <i>miR-21</i> and <i>miR-132</i> expression in the hippocampus were found to be significantly reduced in RT and CT mice compared to control (CON) mice, with a more pronounced difference observed between CT mice and CON mice. Furthermore, there was a significant improvement in the spatial memory ability of RT mice and CT mice, with the spatial memory ability of CT mice showing even greater enhancement. Our findings indicate that the down-regulation of <i>miR-21</i> and <i>miR-132</i> is associated with improved spatial memory, identifying them as potential negative regulators of memory formation. In terms of protein expression, there were no discernible variations in the levels of brain-derived neurotrophic factor and insulin-like growth factor 1 among the various experimental groups. Moreover, the CT mice exhibited a significantly reduced expression level of the tyrosine kinase receptor B protein compared to CON or RT mice. Our study reveals that <i>miR-21</i> and <i>miR-132</i>, as potentially important molecules, provide new research directions for improving spatial memory ability. RT is beneficial for improving cognitive function. Compared to simply engaging in strength training, adopting a specific high-intensity concurrent training program can significantly enhance cognitive abilities, but this may come at the potential cost of a decline in aerobic capacity.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effects of Strength Training and Concurrent Training on Brain-Specific miRNAs Expression in the Mouse Hippocampus

  • 期刊论文

  • 发表日期：

    2026年1月19日

查看全文
  • Rongyan Bai,
  • Haipeng Zhang,
  • Sining Liu,
  • Dong Tian,
  • Shengjia Xu,
  • Weidong Jiang,
  • Mingchao Ding,
  • Qinghao Sun,
  • Chenyu Zhang,
  • Jizheng Ma

摘要

Regular physical activity clearly exerts numerous positive effects on cognitive function. We verified the impact of resistance training (RT) and concurrent training (CT) on cognitive function in mice, as well as the expression of cognition-related genes and brain-specific miRNAs in the hippocampus. In this study, it was demonstrated that RT and CT led to a decrease in miR-21 and miR-132 levels in the hippocampus of mice, and improved their spatial memory ability. The levels of miR-21 and miR-132 expression in the hippocampus were found to be significantly reduced in RT and CT mice compared to control (CON) mice, with a more pronounced difference observed between CT mice and CON mice. Furthermore, there was a significant improvement in the spatial memory ability of RT mice and CT mice, with the spatial memory ability of CT mice showing even greater enhancement. Our findings indicate that the down-regulation of miR-21 and miR-132 is associated with improved spatial memory, identifying them as potential negative regulators of memory formation. In terms of protein expression, there were no discernible variations in the levels of brain-derived neurotrophic factor and insulin-like growth factor 1 among the various experimental groups. Moreover, the CT mice exhibited a significantly reduced expression level of the tyrosine kinase receptor B protein compared to CON or RT mice. Our study reveals that miR-21 and miR-132, as potentially important molecules, provide new research directions for improving spatial memory ability. RT is beneficial for improving cognitive function. Compared to simply engaging in strength training, adopting a specific high-intensity concurrent training program can significantly enhance cognitive abilities, but this may come at the potential cost of a decline in aerobic capacity.