<p>Organosilicon agrochemical adjuvants represent a widely utilized class of spray additives in agricultural applications. However, their impact on crop growth has not been systematically studied. This research is the first to investigate the effects of organosilicon spray adjuvants on physiological indicators and silicon accumulation in maize and wheat under drought stress. During the 7–21 d experimental period, compared to the control group, the organosilicon spray adjuvant maximally increased catalase (CAT) activity in maize and wheat by 54.70 and 121.50%, peroxidase (POD) activity by 55.97 and 44.16%, superoxide dismutase (SOD) activity by 53.57 and 164.30%, and proline content by 1546.73 and 323.79%, respectively. Meanwhile, it maximally reduced malondialdehyde content in maize and wheat by 41.96 and 33.92% and soluble protein content by 66.94 and 42.16%, respectively. Moreover, drought resistance of organosilicon spray adjuvant is comparable to that of silicon fertilizer. At 21&#xa0;days, the organosilicon spray adjuvant induced the absorption of exogenous silicon by the two crops, and the silicon content was 2184 and 4788&#xa0;mg/kg in maize and wheat, respectively. These findings provide novel insights and approaches for enhancing drought tolerance in maize and wheat through the rational combined application of organosilicon spray adjuvants and pesticides.</p>