<p>Rice is one of the significant crops utilized by nearly two-thirds of the world's population. However, various abiotic stresses pose a considerable challenge to fulfilling the increasing food demand and rice production. Salinity stress is one of the most devastating abiotic stress that causes a substantial reduction in rice production by affecting plant growth and metabolism. In the present work, the positive role of 24-epibrassinolide (24-EBL) has been accessed to analyze its alleviatory action under two chloride-dominated salinity stress levels (SS1 and SS2) in two different rice varieties (CSR 30 and PB 1121). Foliar application of 24-EBL improves the germination percentage, plumule and radicle length, seedling fresh and seedling dry weight by improving water uptake, it regulates the uptake of essential nutrients, which were decreased under salinity stress. 24-EBL application enhanced the seed vigor index (SVI), which declined under salt stress conditions. It also enhanced the relative water content (RWC) in leaves and roots and reduced the epibrassinolide (EL) by stabilizing the cell membrane and maintaining the reactive oxygen species (ROS) at the cellular level. Moreover, higher 24-EBL concentrations show a more significant result in improving the plant performance under salinity stress in both varieties. PB 1121 also undergoes more negative effects under salinity stress and an excellent response on 24-EBL application under salinity stress. The current finding indicates that 24-EBL can be a potential alleviator in maintaining plant growth in severely salinity-affected areas. However, more research is still required to thoroughly analyze and understand the mechanism of mitigatory action of 24-EBL under salinity stress and its implication in other research areas.</p>