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<p>Phototherapy is a promising non-invasive treatment method for various diseases. However, the molecular, cellular, and histological mechanisms underlying photobiomodulation (PBM) therapy—previously known as low-level laser therapy—remain unclear. Organic light-emitting diodes (OLEDs) have a thin crystalline structure. Thus, they can be manufactured flexibly, provide uniform light irradiation, and be used to fabricate thin and lightweight devices. In this study, we analyzed the electro-optical characteristics of RGB OLED devices with peak wavelength bands (λₚₑₐₖ) of 620&#xa0;nm (Device A), 532&#xa0;nm (Device B), and 460&#xa0;nm (Device C). Cytotoxicity tests were conducted to assess the effects of these devices on cell viability. The effect of Device A on the viability of human dermal fibroblasts was evaluated using MTT analysis and a scratch wound-healing model. Wound closure rates were quantified through image analysis at 0, 24, and 48&#xa0;h. None of the devices showed significant cytotoxicity. Device A promoted cell migration in an in vitro model. These results provide a foundation for further research on OLED-based PBM systems and wavelength-dependent biological responses.</p>

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Optoelectronic Characteristics of RGB OLED Devices and Enhanced Cell Migration Induced by 620 nm Red Light Irradiation

  • 期刊论文

  • 发表日期：

    2026年7月22日

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  • Sang Hyun Hwang,
  • Jae Sung Ahn,
  • Sang Geon Park

摘要

Phototherapy is a promising non-invasive treatment method for various diseases. However, the molecular, cellular, and histological mechanisms underlying photobiomodulation (PBM) therapy—previously known as low-level laser therapy—remain unclear. Organic light-emitting diodes (OLEDs) have a thin crystalline structure. Thus, they can be manufactured flexibly, provide uniform light irradiation, and be used to fabricate thin and lightweight devices. In this study, we analyzed the electro-optical characteristics of RGB OLED devices with peak wavelength bands (λₚₑₐₖ) of 620 nm (Device A), 532 nm (Device B), and 460 nm (Device C). Cytotoxicity tests were conducted to assess the effects of these devices on cell viability. The effect of Device A on the viability of human dermal fibroblasts was evaluated using MTT analysis and a scratch wound-healing model. Wound closure rates were quantified through image analysis at 0, 24, and 48 h. None of the devices showed significant cytotoxicity. Device A promoted cell migration in an in vitro model. These results provide a foundation for further research on OLED-based PBM systems and wavelength-dependent biological responses.