<p>Packaging waste has become a significant environmental challenge in Ghana, driven by increasing urbanization, inadequate waste management infrastructure, and a reliance on non-biodegradable materials. This study critically examines the adoption of eco-design strategies in packaging sector, identifying key challenges, opportunities, and policy interventions needed to enhance sustainability in Ghana. This review employed a descriptive literature methodology, systematically sourcing data from peer-reviewed journals, institutional reports, and policy documents, and applying thematic analysis to identify trends, challenges, and policy implications. The study reveals that weak regulatory enforcement, high costs of biodegradable materials, technological limitations, and low consumer awareness hinder the widespread adoption of sustainable packaging solutions. Comparative analysis with global best practices highlights the need for strict policy enforcement, including the implementation of Extended Producer Responsibility (EPR) schemes and phased bans on single-use plastics. The study further emphasizes the importance of financial incentives to support local production of biodegradable alternatives and the role of public–private partnerships in scaling up recycling infrastructure. A key contribution of this study is its interdisciplinary approach, integrating policy analysis, consumer behavior insights, and circular economy principles to propose a comprehensive roadmap for sustainable packaging adoption in Ghana. Through fostering multi-sector collaboration, investing in research and innovation, and enhancing consumer education, Ghana can transition toward a circular packaging economy, reducing environmental pollution while promoting economic sustainability. The findings provide a foundation for policymakers, industry stakeholders, and researchers to drive transformative change in Ghana’s packaging sector.</p>