Scholarlink

<p>The inherent non-degradation and potential toxicity of pure carbon nanomaterials in vivo remain the main obstacles to clinical translation. This study attempts to prepare a novel biodegradable caramelized hollow mesoporous carbon nanospheres (CHMCNs) with mesoporous shells and a large cavity, which can be decomposed into small particles (~ 5&#xa0;nm) within 7 days under physiological conditions. By varying the synthesis parameters and templates, CHMCNs with different morphologies can be obtained to meet different application requirements. Meanwhile, CHMCNs exhibit excellent biocompatibility and high drug-loading efficiency, enabling effective delivery of anticancer drugs (DOX) into cells. In addition, due to the good photothermal efficiency (PTT, 29.7%), CHMCNs facilitate pH/NIR dual-responsive drug release under NIR irradiation, resulting in an excellent synergistic chemo-photothermal therapy effect. The results indicate that CHMCNs is a promising drug delivery carrier. In conclusion, this work addresses the non-degradable defects of traditional mesoporous carbon nanomaterials (MCN) and proposes a novel nanocarrier system for tumor treatment.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synthesis and antitumor efficacy of biodegradable hollow mesoporous carbon nanocarriers

  • 期刊论文

  • 发表日期：

    2026年2月4日

查看全文
  • Yuling Zhang,
  • Zhihao Zhao,
  • Yanbing Chen,
  • Jiaru Zhang,
  • Xiao Su,
  • Lanxin Meng,
  • Zhenzhen Xie,
  • Zhiyong Liu,
  • Shiguo Sun

摘要

The inherent non-degradation and potential toxicity of pure carbon nanomaterials in vivo remain the main obstacles to clinical translation. This study attempts to prepare a novel biodegradable caramelized hollow mesoporous carbon nanospheres (CHMCNs) with mesoporous shells and a large cavity, which can be decomposed into small particles (~ 5 nm) within 7 days under physiological conditions. By varying the synthesis parameters and templates, CHMCNs with different morphologies can be obtained to meet different application requirements. Meanwhile, CHMCNs exhibit excellent biocompatibility and high drug-loading efficiency, enabling effective delivery of anticancer drugs (DOX) into cells. In addition, due to the good photothermal efficiency (PTT, 29.7%), CHMCNs facilitate pH/NIR dual-responsive drug release under NIR irradiation, resulting in an excellent synergistic chemo-photothermal therapy effect. The results indicate that CHMCNs is a promising drug delivery carrier. In conclusion, this work addresses the non-degradable defects of traditional mesoporous carbon nanomaterials (MCN) and proposes a novel nanocarrier system for tumor treatment.