Scholarlink

<p>This study presents a genomic and epidemiological exploration of the omicron variant sublineages in Tocantins, Brazil. A total of 556 positive samples, obtained from individuals testing positive for SARS-CoV-2 between December 21, 2021, and June 30, 2023, underwent genome sequencing. Following RNA extraction, cDNA synthesis was executed, and a multiplexed PCR assay was employed for sequencing using the Oxford Nanopore MinION platform. The dispersal patterns of the XBB.1.18.1 lineage were analyzed as a case study, employing maximum likelihood phylogenetic tree construction and a discrete phylogeographical model. Subsequent analyses unveiled 39 sublineages, with BQ.1.1, BA.5.2.1, and BA.1.14.1 emerging as the most prevalent over the studied period. Notably, the emergence of the BQ.1.1 and BQ.1 lineages in Tocantins was observed in November and December 2022, respectively. The XBB.1.18.1 lineage, dominant from January to June 2023, exhibited noteworthy local and international circulation. Through mapping the migration patterns of this lineage, Tocantins was identified as a pivotal node for virus dispersal, with minimal importation cases. The study estimated the global emergence of the XBB.1.18.1 lineage in mid- to late-October 2022. This investigation contributes to comprehending SARS-CoV-2 dynamics in Tocantins and underscores the significance of transportation routes in virus propagation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A comprehensive analysis of the SARS-CoV-2 omicron variant in Tocantins State, Brazil, and tracing the spread of the XBB.1.18.1 lineage

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月23日

查看全文
  • Mateus Silva Santos,
  • Ueric José Borges de Souza,
  • Franciano Dias Pereira Cardoso,
  • Jucimária Dantas Galvão,
  • Fernando Rosado Spilki,
  • Célia Maria de Almeida Soares,
  • Fabrício Souza Campos

摘要

This study presents a genomic and epidemiological exploration of the omicron variant sublineages in Tocantins, Brazil. A total of 556 positive samples, obtained from individuals testing positive for SARS-CoV-2 between December 21, 2021, and June 30, 2023, underwent genome sequencing. Following RNA extraction, cDNA synthesis was executed, and a multiplexed PCR assay was employed for sequencing using the Oxford Nanopore MinION platform. The dispersal patterns of the XBB.1.18.1 lineage were analyzed as a case study, employing maximum likelihood phylogenetic tree construction and a discrete phylogeographical model. Subsequent analyses unveiled 39 sublineages, with BQ.1.1, BA.5.2.1, and BA.1.14.1 emerging as the most prevalent over the studied period. Notably, the emergence of the BQ.1.1 and BQ.1 lineages in Tocantins was observed in November and December 2022, respectively. The XBB.1.18.1 lineage, dominant from January to June 2023, exhibited noteworthy local and international circulation. Through mapping the migration patterns of this lineage, Tocantins was identified as a pivotal node for virus dispersal, with minimal importation cases. The study estimated the global emergence of the XBB.1.18.1 lineage in mid- to late-October 2022. This investigation contributes to comprehending SARS-CoV-2 dynamics in Tocantins and underscores the significance of transportation routes in virus propagation.