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<p><i>Vibrio</i> spp. are endowed with high metabolic diversity, being known for their pathogenicity and ability to acquire and disseminate resistance genes. Here, non-cholera <i>Vibrio</i> spp. were isolated from water samples in Guanabara Bay (GB, Brazil), a recreational estuary. Thirty-five strains non-susceptible to antimicrobials were investigated regarding their pathogenic and resistance profiles. Genes encoding for hemolysins and secretion systems were among the detected virulence traits. Beta-lactam, aminoglycoside, and quinolone resistance genes were investigated in strains phenotypically resistant to these classes, revealing the carriage of the <i>bla</i><sub>SHV</sub> and <i>aac(6′)-Ie-aph(2′)-Ia</i> genes in 50% and 11.1% of the tested strains, respectively. Integrons (classes 1 and 3) and heavy metal resistance genes were detected, likely reflecting local pollution levels. Genome sequencing of five strains revealed further insights regarding their associated resistome and virulome, confirming phenotypic-derived results. Our findings imply that pathogenic and antimicrobial-resistant <i>Vibrio</i> spp. are found in the GB, thus posing a risk to public health.</p>

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Unveiling pathogenicity and resistance profiles of non-cholera Vibrio from an urban estuary

  • 期刊论文

  • 发表日期：

    2025年5月22日

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  • Anna Luiza Bauer Canellas,
  • Bruno Francesco Rodrigues de Oliveira,
  • Marinella Silva Laport

摘要

Vibrio spp. are endowed with high metabolic diversity, being known for their pathogenicity and ability to acquire and disseminate resistance genes. Here, non-cholera Vibrio spp. were isolated from water samples in Guanabara Bay (GB, Brazil), a recreational estuary. Thirty-five strains non-susceptible to antimicrobials were investigated regarding their pathogenic and resistance profiles. Genes encoding for hemolysins and secretion systems were among the detected virulence traits. Beta-lactam, aminoglycoside, and quinolone resistance genes were investigated in strains phenotypically resistant to these classes, revealing the carriage of the blaSHV and aac(6′)-Ie-aph(2′)-Ia genes in 50% and 11.1% of the tested strains, respectively. Integrons (classes 1 and 3) and heavy metal resistance genes were detected, likely reflecting local pollution levels. Genome sequencing of five strains revealed further insights regarding their associated resistome and virulome, confirming phenotypic-derived results. Our findings imply that pathogenic and antimicrobial-resistant Vibrio spp. are found in the GB, thus posing a risk to public health.