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<p>Bone defects combined with extensive periosteal stripping often result in delayed union or non-union, posing a significant challenge in orthopedic surgery. Inspired by the natural periosteum and the physicochemical properties of bone tissue, we developed a novel dual-layer piezoelectric bionic periosteum (DPBP) membrane via electrospinning, aiming to reconstruct the periosteal–bone interface microenvironment and actively promote bone repair. Designed with a hierarchical structure, the DPBP features a dense outer layer serving as a crucial protective barrier, while its biomineralized porous inner layer provides a scaffold for cell attachment. In synergy with ultrasound (US), the inner layer’s piezoelectricity generates endogenous electrical stimulation, promoting stem cell proliferation and osteogenic differentiation by triggering calcium influx and subsequently activating the PI3K/AKT signaling pathway. Furthermore, in vitro studies demonstrated that the DPBP effectively promoted angiogenesis, indicating a synergistic enhancement of osteo-angiogenic coupling. In vivo, in a rat calvarial defect model, the DPBP significantly promoted bone regeneration, enhanced neovascularization, and exhibited beneficial immunomodulatory capabilities. This study presents a bioinspired periosteum substitute that effectively delivers integrated physicochemical signals to actively enhance bone regeneration, offering a promising strategy for challenging clinical applications.</p> Graphical Abstract <p></p>

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Ultrasound Driven Dual-Layer Piezoelectric Bionic Periosteum Recreating the Periosteal-Bone Interface Microenvironment for Accelerated Bone Regeneration

  • 期刊论文

  • 发表日期：

    2026年4月9日

查看全文
  • Chaoyi Zhang,
  • Xin Luo,
  • Zhencheng Xiong,
  • Pu Zhang,
  • Yaojia Zhou,
  • Renliang Zhao,
  • Xiangtian Deng,
  • Dong Wang,
  • Ao Duan,
  • Wenzheng Liu,
  • Pengrui Feng,
  • Liqun Zhang,
  • Guanglin Wang,
  • Xiaoran Hu

摘要

Bone defects combined with extensive periosteal stripping often result in delayed union or non-union, posing a significant challenge in orthopedic surgery. Inspired by the natural periosteum and the physicochemical properties of bone tissue, we developed a novel dual-layer piezoelectric bionic periosteum (DPBP) membrane via electrospinning, aiming to reconstruct the periosteal–bone interface microenvironment and actively promote bone repair. Designed with a hierarchical structure, the DPBP features a dense outer layer serving as a crucial protective barrier, while its biomineralized porous inner layer provides a scaffold for cell attachment. In synergy with ultrasound (US), the inner layer’s piezoelectricity generates endogenous electrical stimulation, promoting stem cell proliferation and osteogenic differentiation by triggering calcium influx and subsequently activating the PI3K/AKT signaling pathway. Furthermore, in vitro studies demonstrated that the DPBP effectively promoted angiogenesis, indicating a synergistic enhancement of osteo-angiogenic coupling. In vivo, in a rat calvarial defect model, the DPBP significantly promoted bone regeneration, enhanced neovascularization, and exhibited beneficial immunomodulatory capabilities. This study presents a bioinspired periosteum substitute that effectively delivers integrated physicochemical signals to actively enhance bone regeneration, offering a promising strategy for challenging clinical applications.

Graphical Abstract