Scholarlink

<p>Wound treatment is a major global clinical challenge associated with substantial economic burden and a negative impact on patient quality. The clinical translation of advanced wound dressings is hindered by fabrication complexity for exudate control and the inadequacy of single-point sensors. Here, a smart fibrous platform consisting of a fibrous membrane and a wireless five-channel optoelectronic circuit was proposed for directional exudate transport, real-time spatial pH monitoring, and wound-healing promotion. Inspired by vascular plants, the gradient hierarchically designed fibrous membrane composed of polycaprolactone, collagen, and anthocyanin was fabricated through a single-solution continuous electrospinning process by adjusting spinning flow rate and driving directional exudate transport from the wound to the exterior. The anthocyanin color changes were converted to voltage by a wireless five-channel optoelectronic circuit, enabling spatial pH monitoring in the pH range of 3–11 with a sensitivity of 37 mV/pH and allowing for the early detection of wound infection by capturing its unique early peripheral alkalinization. The platform also demonstrated excellent cytocompatibility and hemocompatibility with potent antibacterial efficacy (&gt; 97%). <i>In vivo</i> assays and histopathological studies suggest that the platform accelerates wound closure by about 17.5% over commercial gauze while promoting collagen deposition, angiogenesis, and inflammatory factors expression reduction. By unifying an engineered exudate management mechanism with spatially resolved diagnostics and bioactive therapy, this work offers a new paradigm for the rational design of intelligent wound care platforms.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A Smart Fibrous Platform with a Gradient Hierarchical Structure for Wound Exudate Management and Real-time Spatial pH Monitoring

  • 期刊论文

  • 发表日期：

    2026年1月28日

查看全文
  • Junfeng Li,
  • Zihan Kou,
  • Jie Shi,
  • Yanqing Liu,
  • Ziying Wang,
  • Xiangyan Meng,
  • Chenxi Li,
  • Zhonghong Yang,
  • Zhaoyu Yin,
  • Qi An,
  • Xinyu Shi,
  • Xiaoya Wang,
  • Haojun Fan,
  • Jiameng Li

摘要

Wound treatment is a major global clinical challenge associated with substantial economic burden and a negative impact on patient quality. The clinical translation of advanced wound dressings is hindered by fabrication complexity for exudate control and the inadequacy of single-point sensors. Here, a smart fibrous platform consisting of a fibrous membrane and a wireless five-channel optoelectronic circuit was proposed for directional exudate transport, real-time spatial pH monitoring, and wound-healing promotion. Inspired by vascular plants, the gradient hierarchically designed fibrous membrane composed of polycaprolactone, collagen, and anthocyanin was fabricated through a single-solution continuous electrospinning process by adjusting spinning flow rate and driving directional exudate transport from the wound to the exterior. The anthocyanin color changes were converted to voltage by a wireless five-channel optoelectronic circuit, enabling spatial pH monitoring in the pH range of 3–11 with a sensitivity of 37 mV/pH and allowing for the early detection of wound infection by capturing its unique early peripheral alkalinization. The platform also demonstrated excellent cytocompatibility and hemocompatibility with potent antibacterial efficacy (> 97%). In vivo assays and histopathological studies suggest that the platform accelerates wound closure by about 17.5% over commercial gauze while promoting collagen deposition, angiogenesis, and inflammatory factors expression reduction. By unifying an engineered exudate management mechanism with spatially resolved diagnostics and bioactive therapy, this work offers a new paradigm for the rational design of intelligent wound care platforms.

Graphical Abstract