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<p>The present study discovers differentially expressed genes that have a particular impact on gastric cancer. The Gene Expression Omnibus was used to extract the transcriptome profiles of gastric cancer and noncancerous tissue samples to identify these genes. Differentially expressed genes were obtained utilizing the GEO2R tool. Genes frequently observed among upregulated genes in these profiles were deemed to represent a gastric cancer gene set. The ontological function of the gastric cancer gene set was then investigated using the Molecular Signatures Database, and the effects of gene mutations on the gene expression profile of stomach cancer were studied using the cBioPortal database. OncoPrint results had 33 amplified genes in over 5% of patients with stomach cancer. The Dependency Map portal's gene effect score further examines these amplified genes. The following 12 genes, <i>COL4A1, TNS4, SULF1, COL11A1, PMEPA1, COL5A1, THBS2, COL5A2, FKBP10, FSCN1, TNFRSF11B, and BUB1</i>, have been identified and considered as gastric cancer hub genes due to their involvement in significantly amplified and higher gene effect scores in gastric cancer. The ROC curve plot also showed increased sensitivity and specificity for the hub genes in stomach tumors. Moreover, the hub genes found are primarily amplified and implicated in the carcinogenesis of gastric tumors of the intestinal subtype. Furthermore, poor survival patterns were observed in the intestinal subtype of gastric cancer patients with higher expression of these hub genes. Thus, the current study identified hub genes for stomach cancer that may be targeted as prognostic and diagnostic indicators for this type of cancer.</p>

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Amplified gene expressions were implicated in the gastric carcinogenesis of the intestinal subtype

  • 期刊论文

  • 发表日期：

    2026年1月13日

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  • Karthik Balakrishnan

摘要

The present study discovers differentially expressed genes that have a particular impact on gastric cancer. The Gene Expression Omnibus was used to extract the transcriptome profiles of gastric cancer and noncancerous tissue samples to identify these genes. Differentially expressed genes were obtained utilizing the GEO2R tool. Genes frequently observed among upregulated genes in these profiles were deemed to represent a gastric cancer gene set. The ontological function of the gastric cancer gene set was then investigated using the Molecular Signatures Database, and the effects of gene mutations on the gene expression profile of stomach cancer were studied using the cBioPortal database. OncoPrint results had 33 amplified genes in over 5% of patients with stomach cancer. The Dependency Map portal's gene effect score further examines these amplified genes. The following 12 genes, COL4A1, TNS4, SULF1, COL11A1, PMEPA1, COL5A1, THBS2, COL5A2, FKBP10, FSCN1, TNFRSF11B, and BUB1, have been identified and considered as gastric cancer hub genes due to their involvement in significantly amplified and higher gene effect scores in gastric cancer. The ROC curve plot also showed increased sensitivity and specificity for the hub genes in stomach tumors. Moreover, the hub genes found are primarily amplified and implicated in the carcinogenesis of gastric tumors of the intestinal subtype. Furthermore, poor survival patterns were observed in the intestinal subtype of gastric cancer patients with higher expression of these hub genes. Thus, the current study identified hub genes for stomach cancer that may be targeted as prognostic and diagnostic indicators for this type of cancer.