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<p>In their recent <i>Cell</i> publication, Kang et al. shed light on a critical yet poorly understood aspect of cancer biology: how tumor cells preserve oncogenic extrachromosomal DNA (ecDNA). The study reveals that DNA topoisomerases frequently introduce double strand breaks into ecDNA, triggering its rapid degradation. Importantly, the authors identify a DNA damage repair pathway that counteracts this degradation by re-circularizing ecDNA. Given the potent oncogenic potential of ecDNA, these findings not only deepen our mechanistic understanding of ecDNA maintenance but also highlight promising new therapeutic targets in ecDNA-positive cancers.</p>

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Targeting ATM kinase: a promising strategy to disrupt ecDNA maintenance in cancer

  • 期刊论文

  • 发表日期：

    2025年7月10日

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  • Zhuoyang Zhao,
  • Shunichi Takeda

摘要

In their recent Cell publication, Kang et al. shed light on a critical yet poorly understood aspect of cancer biology: how tumor cells preserve oncogenic extrachromosomal DNA (ecDNA). The study reveals that DNA topoisomerases frequently introduce double strand breaks into ecDNA, triggering its rapid degradation. Importantly, the authors identify a DNA damage repair pathway that counteracts this degradation by re-circularizing ecDNA. Given the potent oncogenic potential of ecDNA, these findings not only deepen our mechanistic understanding of ecDNA maintenance but also highlight promising new therapeutic targets in ecDNA-positive cancers.