<p>Climate change needs to raise crop security applications while introducing highly productive cultivars resistant to abiotic stresses. Grafted plants could be more vigorous and healthier due to an ample supply of water and nutrients through rootstocks that modify their development. The deep penetration ability and adaptability to the existing environment are of key importance for rootstock. These are the significant reasons why all the researchers struggle to introduce bred rootstocks which can encourage scion growth and efficiency under harsh environments, regulating stomatal conductance and water conservation.&#xa0;A research experiment on rootstock-scion success in commercial grapevine cultivars (Sugraone, King Ruby and Thompson Seedless) enhanced by kinetin concentrations (0, 75, 150 and 225 mg L^− 1) was carried out using Randomized Complete Block Design (RCBD) having two factors and a combination of twelve treatments replicated three times to study the growth and physiological responses of grape scions.&#xa0;The highest graft success was recorded (60.00%) indicating the clear placement of grafted union, minimum days to bud sprout (19.53), callus formation rate (3.85), shoot length (38.33&#xa0;cm), shoot diameter (4.59&#xa0;cm), leaf area (92 cm²), chlorophyll content (30.26 SPAD), leaves fresh weight (4.13&#xa0;g) and leaves dry weight (2.14&#xa0;g). The highest enzymatic activities of peroxidase (6.36 U mg^− 1) and catalase (6.23 U mg^− 1) were recorded in Sugraone cultivar with the application of 225 mg L^− 1.&#xa0;It’s concluded that Sugraone is the most suitable and compatible cultivar with Dogridge rootstock and application of kinetin at the rate of 225 mg L^− 1 is recommended to enhance the success of rootstock-scion interaction.</p>