Aims <p>Arsenic (As) toxicity has detrimental effect on both the agricultural productivity (plant metabolism) as well as human health. From groundwater to every ecological niche, arsenic is prevalent. Nowadays, eco-friendly management of arsenic is in the scientific appetite. In this context, among the phenomenal biological remediation techniques, plant-microbes interaction-based remediation process is the more proficient one than application of individual plant or microbe. Plant-associated symbiotic microbes like endophytic bacteria not only promote plant’s detoxification against heavy metals like As but also ameliorate their host-plant growth promoting (PGP) attributes. Endophytic bacterial strategies for detoxification of As include biochemical, physiological, and molecular approaches, mainly arsenate reduction, methylation, and phytochelatin complexation. In addition to these, indole-3-acetic acid (IAA), 1-aminocyclopropane-1-carboxylate deaminase (ACCD), and siderophore production, phosphate solubilization, and biofilm formation count as their PGP potential.</p> Methods <p>In this review, 795 publications were retrieved from the Web of Science (WOS) and Scopus, using broad keywords related to bacteria and endophytic bacteria mediated arsenic remediation from 2000 to 2024.</p> Results <p>In this review, multidimensional mechanisms based on the endophytic bacterial resources on As bioremediation, have been described, reported over the last couple of decades. Proteobacteria were found to be the most dominant endophytic bacterial community, consisting of 59% while actinobacteria, firmicutes, and bacteroidetes occupied 18%, 18%, and 5%, respectively.</p> Conclusion <p>This review highlights critical factors regarding the selection and application of endophytic bacteria in As-contaminated environments to augment plant and human health management and promote the Sustainable Development Goals (SDGs).</p>